{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:24:45Z","timestamp":1767666285250,"version":"3.41.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2002,8,15]],"date-time":"2002-08-15T00:00:00Z","timestamp":1029369600000},"content-version":"unspecified","delay-in-days":45,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> This study examined the effects of psychological stress on platelet \u03b12-adrenergic receptor (\u03b12-AR) binding sites in relation to stress-induced anxiety and changes in the inflammatory response system (IRS).<\/jats:p>\n\t  <jats:p><jats:bold>Methods.<\/jats:bold> The maximum number of binding sites (Bmax) and their affinity (Kd) for [<jats:sup>3<\/jats:sup>H]-rauwolscine, a selective \u03b12-AR antagonist, and the stimulated production of tumor necrosis factor-\u03b1 (TNF\u03b1), the Th1-like cytokine, interferon-\u03b3 (IFN\u03b3), and the Th2-like cytokines, interleukin-10 (IL-10) and IL-5, were measured in 35 university students a few weeks before (baseline) as well as on the day before a difficult, oral examination (stress condition). The State-Trait-Anxiety Inventory (STAI)- was recorded during both conditions. The Minnesota Multiphase Personality Inventory (MMPI-2<jats:sup>TM<\/jats:sup>) was used to assess psychasthenia (Scale 7).<\/jats:p>\n\t  <jats:p><jats:bold>Results.<\/jats:bold> Academic examination stress induced a significant increase in \u03b12-AR density in students whose STAI scores increased in the stress period, in female students and in students who scored higher on psychasthenia. There were significant and positive correlations between stress-induced anxiety and changes in \u03b12-AR density. Stress-induced anxiety was accompanied by a pro-inflammatory and Th1-like response, i.e. increased IFN\u03b3 and TNF\u03b1 production. The stress-induced changes in platelet \u03b12-AR density were significantly and positively related to the production of TNF\u03b1, IL-10 and IL-5 and negatively to that of IFN\u03b3.<\/jats:p>\n\t  <jats:p><jats:bold>Conclusions.<\/jats:bold> Subchronic psychological stress in humans induces increased \u03b12-AR density, which is related to stress-induced anxiety, an anxiety-prone constitution and female sex. Increased \u03b12-AR density is accompanied by a Th2-like response and increased TNF\u03b1 production. The results suggest that: (<jats:italic>i<\/jats:italic>) \u03b12-AR density is sensitive to graded differences in stress-induced anxiety; and (<jats:italic>ii<\/jats:italic>) psychological stress is accompanied by intertwined responses in the catecholaminergic system, such as \u03b12-ARs, and the IRS, such as Th1\/Th2-like functions and the production of TNF\u03b1.<\/jats:p>","DOI":"10.1017\/s0033291702005925","type":"journal-article","created":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T12:52:01Z","timestamp":1032526321000},"page":"919-928","source":"Crossref","is-referenced-by-count":19,"title":["Platelet \u03b12-adrenoceptor density in humans: relationships to stress-induced anxiety, psychasthenic constitution, gender and stress-induced changes in the inflammatory response system"],"prefix":"10.1017","volume":"32","author":[{"given":"M.","family":"MAES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"VAN GASTEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"DELMEIRE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"KENIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"BOSMANS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"SONG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2002,8,15]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291702005925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T15:52:39Z","timestamp":1750434759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291702005925\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["S0033291702005925"],"URL":"https:\/\/doi.org\/10.1017\/s0033291702005925","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"type":"print","value":"0033-2917"},{"type":"electronic","value":"1469-8978"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}