{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:40:52Z","timestamp":1771864852077,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2002,11,29]],"date-time":"2002-11-29T00:00:00Z","timestamp":1038528000000},"content-version":"unspecified","delay-in-days":28,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold>\u2002Somatization is a clinical phenomenon characterized by multiple, medically unexplained somatic symptoms. The pathophysiology remains unknown. We aimed to test the hypothesis of a central nervous system dysfunction in the pathophysiology of this disorder.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold>\u2002We studied 10 female patients diagnosed as having somatization disorder or undifferentiated somatoform disorder with no current Axis I disorders according to DSM-IV. They were compared with 17 healthy female volunteers using brain [18F]-fluorodeoxyglucose-PET with MRI reference.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold>\u2002The patients had lower cerebral metabolism rates of glucose (<jats:italic>P<\/jats:italic>&lt;0\u00b705) in both caudate nuclei, left putamen and right precentral gyrus compared with healthy volunteers.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold>\u2002This is the first study to demonstrate changes in brain metabolism in somatizing women. The regional cerebral hypometabolism is probably associated with the pathophysiology of somatization.<\/jats:p>","DOI":"10.1017\/s0033291702006578","type":"journal-article","created":{"date-parts":[[2002,12,4]],"date-time":"2002-12-04T14:58:36Z","timestamp":1039013916000},"page":"1379-1385","source":"Crossref","is-referenced-by-count":27,"title":["Severe somatization in women is associated with altered cerebral glucose metabolism"],"prefix":"10.1017","volume":"32","author":[{"given":"M.","family":"HAKALA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"KARLSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"RUOTSALAINEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"KOPONEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"BERGMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"STENMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-P.","family":"KELAVUORI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"AALTO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"KURKI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"NIEMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2002,11,29]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291702006578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:24:43Z","timestamp":1557188683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291702006578\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["S0033291702006578"],"URL":"https:\/\/doi.org\/10.1017\/s0033291702006578","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}