{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:20:33Z","timestamp":1791120033872,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T00:00:00Z","timestamp":1103587200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Despite the availability of efficacious medications and psychotherapies, care of bipolar disorder in everyday practice is often deficient. This trial evaluated the effectiveness of a multi-component care management program in a population-based sample of people with bipolar disorder.<\/jats:p>\n\t  <jats:p><jats:bold>Method.<\/jats:bold> Four hundred and forty-one patients treated for bipolar disorder during the prior year were randomly assigned to continued usual care or usual care plus a systematic care management program including: initial assessment and care planning, monthly telephone monitoring including brief symptom assessment and medication monitoring, feedback to and coordination with the mental health treatment team, and a structured group psychoeducational program \u2013 all provided by a nurse care manager. Blinded quarterly assessments generated week-by-week ratings of severity of depression and mania symptoms using the Longitudinal Interval Follow-Up Evaluation.<\/jats:p>\n\t  <jats:p><jats:bold>Results.<\/jats:bold> Participants assigned to the intervention group had significantly lower mean mania ratings averaged across the 12-month follow-up period (<jats:italic>Z<\/jats:italic>=2\u00b744, <jats:italic>p<\/jats:italic>=0\u00b7015) and approximately one-third less time in hypomanic or manic episode (2\u00b759 weeks <jats:italic>v<\/jats:italic>. 1\u00b769 weeks). Mean depression ratings across the entire follow-up period did not differ significantly between the two groups, but the intervention group showed a greater decline in depression ratings over time (<jats:italic>Z<\/jats:italic> statistic for group-by-time interaction=1\u00b798, <jats:italic>p<\/jats:italic>=0\u00b7048).<\/jats:p>\n\t  <jats:p><jats:bold>Conclusions.<\/jats:bold> A systematic care program for bipolar disorder significantly reduces risk of mania over 12 months. Preliminary results suggest a growing effect on depression over time, but longer follow-up will be needed.<\/jats:p>","DOI":"10.1017\/s0033291704002624","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T20:59:00Z","timestamp":1103749140000},"page":"13-24","source":"Crossref","is-referenced-by-count":73,"title":["Randomized trial of a population-based care program for people with bipolar disorder"],"prefix":"10.1017","volume":"35","author":[{"given":"GREGORY E.","family":"SIMON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EVETTE J.","family":"LUDMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00dcRGEN","family":"UN\u00dcTZER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK S.","family":"BAUER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BELINDA","family":"OPERSKALSKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CAROLYN","family":"RUTTER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2004,12,21]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291704002624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T20:03:40Z","timestamp":1750449820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291704002624\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,21]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0033291704002624"],"URL":"https:\/\/doi.org\/10.1017\/s0033291704002624","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,21]]}}}