{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T18:31:17Z","timestamp":1726425077652},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> In bulimic syndromes, binge episodes are thought to be caused by dietary restraint and negative moods. However, as central serotonin (5-hydroxytryptamine: 5-HT) mechanisms regulate appetite and mood, the 5-HT system could be implicated in diet- and mood-based binge antecedents.<\/jats:p><jats:p><jats:bold>Method.<\/jats:bold> We used hand-held computers to obtain repeated \u2018online\u2019 measurements of eating behaviors, moods, and self-concepts in 21 women with bulimic syndromes, and modeled 5-HT system activity with a measure of platelet [<jats:sup>3<\/jats:sup>H]paroxetine-binding density.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Mood and self-concept ratings were found to be worse before binge episodes (than at other moments), and cognitive restraint was increased. After binges, mood and self-concept deteriorated further, and thoughts of dieting became more intense. Intriguingly, lower paroxetine-binding density predicted poorer mood and self-concept before a binge, larger post-binge decrements in mood and self-concept, and larger post-binge increases in dietary restraint.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Paroxetine binding thus seemed to reflect processes that impacted upon mood-related antecedents to binge episodes, and consequences implicating mood and dietary restraint.<\/jats:p>","DOI":"10.1017\/s0033291705005817","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T06:19:59Z","timestamp":1125037199000},"page":"1553-1562","source":"Crossref","is-referenced-by-count":30,"title":["Mood- and restraint-based antecedents to binge episodes in bulimia nervosa: possible influences of the serotonin system"],"prefix":"10.1017","volume":"35","author":[{"given":"HOWARD","family":"STEIGER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LISE","family":"GAUVIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARLA J.","family":"ENGELBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. M. K. NG","family":"YING KIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MIMI","family":"ISRAEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STEPHEN A.","family":"WONDERLICH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JODIE","family":"RICHARDSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,8,26]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291705005817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T15:48:07Z","timestamp":1556898487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291705005817\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,26]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0033291705005817"],"URL":"https:\/\/doi.org\/10.1017\/s0033291705005817","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,26]]}}}