{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:31:12Z","timestamp":1777465872574,"version":"3.51.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T00:00:00Z","timestamp":1136851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Panic disorder is a prevalent, often disabling, disorder among primary-care patients, but there are large gaps in quality of treatment in primary care. This study describes the incremental cost-effectiveness of a combined cognitive behavioral therapy (CBT) and pharmacotherapy intervention for patients with panic disorder <jats:italic>versus<\/jats:italic> usual primary-care treatment.<\/jats:p><jats:p><jats:bold>Method.<\/jats:bold> This randomized control trial recruited 232 primary-care patients meeting DSM-IV criteria for panic disorder from March 2000 to March 2002 from six primary-care clinics from university-affiliated clinics at the University of Washington (Seattle) and University of California (Los Angeles and San Diego). Patients were randomly assigned to receive either treatment as usual or a combined CBT and pharmacotherapy intervention for panic disorder delivered in primary care by a mental health therapist. Intervention patients had up to six sessions of CBT modified for the primary-care setting in the first 12 weeks, and up to six telephone follow-ups over the next 9 months. The primary outcome variables were total out-patient costs, anxiety-free days (AFDs) and quality adjusted life-years (QALYs).<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Relative to usual care, intervention patients experienced 60\u00b74 [95% confidence interval (CI) 42\u00b79\u201377\u00b79] more AFDs over a 12-month period. Total incremental out-patient costs were $492 higher (95% CI $236\u2013747) in intervention <jats:italic>versus<\/jats:italic> usual care patients with a cost per additional AFD of $8.40 (95% CI $2.80\u201314.0) and a cost per QALY ranging from $14158 (95% CI $6791\u201321496) to $24776 (95% CI $11885\u201337618). The cost per QALY estimate is well within the range of other commonly accepted medical interventions such as statin use and treatment of hypertension.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> The combined CBT and pharmacotherapy intervention was associated with a robust clinical improvement compared to usual care with a moderate increase in ambulatory costs.<\/jats:p>","DOI":"10.1017\/s0033291705006896","type":"journal-article","created":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T09:59:23Z","timestamp":1136887163000},"page":"353-363","source":"Crossref","is-referenced-by-count":72,"title":["Incremental cost-effectiveness of a collaborative care intervention for panic disorder"],"prefix":"10.1017","volume":"36","author":[{"given":"WAYNE","family":"KATON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOAN","family":"RUSSO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CATHY","family":"SHERBOURNE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MURRAY","family":"B. STEIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MICHELLE","family":"CRASKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MING-YU","family":"FAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETER","family":"ROY-BYRNE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,1,10]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291705006896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T17:35:19Z","timestamp":1554399319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291705006896\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,10]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0033291705006896"],"URL":"https:\/\/doi.org\/10.1017\/s0033291705006896","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,10]]}}}