{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:44:23Z","timestamp":1793216663743,"version":"4.5.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T00:00:00Z","timestamp":1183593600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec id=\"S0033291707001110_sec_a001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite increasing awareness of the extent and severity of cognitive deficits in major depressive disorder (MDD), trials of cognitive remediation have not been conducted. We conducted a 10-week course of cognitive remediation in patients with long-term MDD to probe whether deficits in four targeted cognitive domains, (i) memory, (ii) attention, (iii) executive functioning and (iv) psychomotor speed, could be improved by this intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291707001110_sec_a002\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We administered a computerized cognitive retraining package (PSSCogReHab) with demonstrated efficacy to 12 stable patients with recurrent MDD. Twelve matched patients with MDD and a group of healthy control participants were included for comparison; neither comparator group received the intervention that involved stimulation of cognitive functions through targeted, repetitive exercises in each domain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291707001110_sec_a003\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients who received cognitive training improved on a range of neuropsychological tests targeting attention, verbal learning and memory, psychomotor speed and executive function. This improvement exceeded that observed over the same time period in a group of matched comparisons. There was no change in depressive symptom scores over the course of the trial, thus improvement in cognitive performance occurred independent of other illness variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291707001110_sec_a004\" sec-type=\"conclusion\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results provide preliminary evidence that improvement of cognitive functions through targeted, repetitive exercises is a viable method of cognitive remediation in patients with recurrent MDD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291707001110","type":"journal-article","created":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T06:37:21Z","timestamp":1183617441000},"page":"1229-1238","source":"Crossref","is-referenced-by-count":121,"title":["Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study"],"prefix":"10.1017","volume":"37","author":[{"given":"SAFA","family":"ELGAMAL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARGARET C.","family":"McKINNON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KARUNA","family":"RAMAKRISHNAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RUSSELL T.","family":"JOFFE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GLENDA","family":"MacQUEEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,7,5]]},"reference":[{"key":"S0033291707001110_ref002","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2003.00090.x"},{"key":"S0033291707001110_ref039","volume-title":"Wechsler Adult Intelligence Scale","author":"Wechsler","year":"1997"},{"key":"S0033291707001110_ref023","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701004834"},{"key":"S0033291707001110_ref022","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0337481100"},{"key":"S0033291707001110_ref040","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.23.2805"},{"key":"S0033291707001110_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707070178"},{"key":"S0033291707001110_ref007","volume-title":"Structured Clinical Interview for DSM-IV-TR Axis 1 Disorders\u00a0\u2013\u00a0Patient Edition","author":"First","year":"2001"},{"key":"S0033291707001110_ref028","volume-title":"The Halstead\u2013Reitan Neuropsychological Test Battery","author":"Reitan","year":"1985"},{"key":"S0033291707001110_ref009","first-page":"97","article-title":"Executive functioning in unipolar depression: a review","volume":"28","author":"Fossati","year":"2002","journal-title":"Encephale"},{"key":"S0033291707001110_ref042","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.133.5.429"},{"key":"S0033291707001110_ref037","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a006919"},{"key":"S0033291707001110_ref033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-6916.2006.00005.x"},{"key":"S0033291707001110_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2626(03)00141-6"},{"key":"S0033291707001110_ref029","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.125.5.544"},{"key":"S0033291707001110_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2004.03.003"},{"key":"S0033291707001110_ref012","doi-asserted-by":"publisher","DOI":"10.1080\/13803390500246944"},{"key":"S0033291707001110_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2003.08.002"},{"key":"S0033291707001110_ref004","volume-title":"PSSCogReHab Version 95: Technical Manual","author":"Bracy","year":"1994"},{"key":"S0033291707001110_ref001","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.8.763"},{"key":"S0033291707001110_ref003","volume-title":"Multilingual Aphasia Examination","author":"Benton","year":"1983"},{"key":"S0033291707001110_ref032","volume-title":"Ruff 2and7 Selective Attention Test. 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