{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:10:07Z","timestamp":1792062607235,"version":"4.4.0"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T00:00:00Z","timestamp":1220832000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec id=\"S0033291708003383_sec_001\"><jats:title>Background<\/jats:title><jats:p>Several prior reports have found that some young children with autism spectrum disorder [ASD; including autism and Asperger's syndrome and pervasive developmental disorder\u00a0\u2013\u00a0not otherwise specified (PDD-NOS)] have a significant increase in head size and brain weight. However, the findings from older children and adults with ASD are inconsistent. This may reflect the relatively small sample sizes that were studied, clinical heterogeneity, or age-related brain differences.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291708003383_sec_a002\"><jats:title>Method<\/jats:title><jats:p>Hence, we measured head size (intracranial volume), and the bulk volume of ventricular and peripheral cerebrospinal fluid (CSF), lobar brain, and cerebellum in 114 people with ASD and 60 controls aged between 18 and 58 years. The ASD sample included 80 people with Asperger's syndrome, 28 with autism and six with PDD-NOS.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291708003383_sec_a003\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There was no significant between-group difference in head and\/or lobar brain matter volume. However, compared with controls, each ASD subgroup had a significantly smaller cerebellar volume, and a significantly larger volume of peripheral CSF.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291708003383_sec_a004\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Within ASD adults, the bulk volume of cerebellum is reduced irrespective of diagnostic subcategory. Also the significant increase in peripheral CSF may reflect differences in cortical maturation and\/or ageing.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291708003383","type":"journal-article","created":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T09:49:52Z","timestamp":1220867392000},"page":"337-346","source":"Crossref","is-referenced-by-count":77,"title":["Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults"],"prefix":"10.1017","volume":"39","author":[{"given":"B.","family":"Hallahan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.\u00a0M.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"McAlonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Loth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Toal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u00a0C.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u00a0G.\u00a0M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,9,8]]},"reference":[{"key":"S0033291708003383_ref015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805263182102"},{"key":"S0033291708003383_ref021","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.7.1290"},{"key":"S0033291708003383_ref002","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5308.1940"},{"key":"S0033291708003383_ref025","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg110"},{"key":"S0033291708003383_ref004","doi-asserted-by":"publisher","DOI":"10.1023\/B:CEMN.0000005322.27203.73"},{"key":"S0033291708003383_ref046","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.4.561"},{"key":"S0033291708003383_ref049","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1523\/JNEUROSCI.19-13-05632.1999","article-title":"Spatial attention deficits in patients with acquired or developmental cerebellar abnormality","volume":"19","author":"Townsend","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"S0033291708003383_ref029","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.5.1041"},{"key":"S0033291708003383_ref024","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh330"},{"key":"S0033291708003383_ref036","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520420111032"},{"key":"S0033291708003383_ref037","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830070031007"},{"key":"S0033291708003383_ref048","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.2.184"},{"key":"S0033291708003383_ref052","doi-asserted-by":"publisher","DOI":"10.12968\/hosp.2004.65.9.15984"},{"key":"S0033291708003383_ref041","first-page":"145","article-title":"An MRI study of brain size in autism","volume":"152","author":"Piven","year":"1995","journal-title":"American Journal of Psychiatry"},{"key":"S0033291708003383_ref051","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(99)00258-5"},{"key":"S0033291708003383_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.11.2203"},{"key":"S0033291708003383_ref039","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1024"},{"key":"S0033291708003383_ref011","first-page":"184","article-title":"Cerebral lobes in autism: early hyperplasia and abnormal age effects","volume":"59","author":"Carper","year":"2002","journal-title":"Neuroimage"},{"key":"S0033291708003383_ref040","volume-title":"SPSS Survival Manual. 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