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Functional imaging has demonstrated an increase in amygdala response to emotional faces in subjects with social anxiety. Nevertheless, it is unclear to what extent visual areas processing faces influence amygdala reactivity in different socially anxious individuals. We assessed the influence of the fusiform gyrus activation on amygdala response to emotional faces in the non-clinical range of social anxiety.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329170800500X_sec_a002\">\n\t    <jats:title>Method<\/jats:title>\n\t    <jats:p>Twenty-two normal subjects showing a wide range in social anxiety scores were examined using functional magnetic resonance imaging (fMRI) during the processing of happy and fearful faces. A dimensional analysis approach was used involving voxel-wise mapping of the correlation between subjects' social anxiety scores and amygdala activation, before and after controlling for fusiform gyrus activation.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329170800500X_sec_a003\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>We observed that only after controlling for subjects' level of activation of the fusiform gyrus was there an association between social anxiety ratings and amygdala response to both happy and fearful faces. The fusiform gyrus influence was more robust during the fear condition. Of note, fusiform gyrus response to fearful faces showed a negative correlation with additional behavioral assessments related to avoidance, including social anxiety scores, harm avoidance and sensitivity to punishment.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S003329170800500X_sec_a004\" sec-type=\"conclusion\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Relevant interactions among the emotional face-processing stages exist in the non-clinical range of social anxiety that may ultimately attenuate amygdala responses. Future research will help to establish the role of this effect in a clinical context.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s003329170800500x","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T09:06:31Z","timestamp":1232528791000},"page":"1177-1187","source":"Crossref","is-referenced-by-count":63,"title":["Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety"],"prefix":"10.1017","volume":"39","author":[{"given":"J.","family":"Pujol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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