{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:30:44Z","timestamp":1780511444306,"version":"3.54.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T00:00:00Z","timestamp":1263168000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec id=\"S0033291709992182_sec_a001\"><jats:title>Background<\/jats:title><jats:p>The effects of hospital-based rehabilitation including weekly supportive psychodynamic therapy compared with specialized assertive intervention and standard treatment has not previously been investigated in first-episode psychosis. The aim of the study was to examine long-term effect on use of institutional care of different intensive interventions for patients with first-episode schizophrenia spectrum disorder on use of psychiatric bed days and days in supported housing.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291709992182_sec_a002\"><jats:title>Method<\/jats:title><jats:p>A total of 94 severely ill patients with first-episode schizophrenia spectrum disorders were included in a special part of the Copenhagen OPUS trial and randomized to either the specialized assertive intervention program (OPUS), standard treatment or hospital-based rehabilitation.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291709992182_sec_a003\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>It was a stable pattern that patients randomized to hospital-based rehabilitation spent more days in psychiatric wards and in supported housing throughout the 5-year follow-up period compared with the two other groups. Patients in OPUS treatment spent significantly fewer days in psychiatric wards and supported housing in the first 3 years compared with patients in hospital-based rehabilitation. Due to attrition and small sample size, differences in level of psychotic and negative symptoms at 5-year follow-up could not be evaluated.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291709992182_sec_a004\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>The study indicates that hospital-based rehabilitation together with weekly supportive psychodynamic therapy was associated with a continued increased use of psychiatric bed days and days in supported housing. The data cannot justify using hospital-based rehabilitation in first-episode psychosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291709992182","type":"journal-article","created":{"date-parts":[[2010,1,11]],"date-time":"2010-01-11T04:48:47Z","timestamp":1263185327000},"page":"1619-1626","source":"Crossref","is-referenced-by-count":25,"title":["Deinstitutionalization revisited: a 5-year follow-up of a randomized clinical trial of hospital-based rehabilitation <i>versus<\/i> specialized assertive intervention (OPUS) <i>versus<\/i> standard treatment for patients with first-episode schizophrenia spectrum disorders"],"prefix":"10.1017","volume":"40","author":[{"given":"M.","family":"Nordentoft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"\u00d8hlenschl\u00e6ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thorup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Jeppesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bertelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,1,11]]},"reference":[{"key":"S0033291709992182_ref009","article-title":"Assertive Community Treatment for people with severe mental disorders","volume":"5","author":"Marshall","year":"2003","journal-title":"Cochrane Library"},{"key":"S0033291709992182_ref015","doi-asserted-by":"publisher","DOI":"10.1080\/08039480701644652"},{"key":"S0033291709992182_ref006","first-page":"973","article-title":"When there are almost no state hospital beds left. 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