{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:24:29Z","timestamp":1791066269268,"version":"4.1.0"},"reference-count":56,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec id=\"S0033291710001303_sec_a001\"><jats:title>Background<\/jats:title><jats:p>Studies investigating neurocognitive impairment in subjects with eating disorders (EDs) have reported heterogeneous patterns of impairment and, in some instances, no dysfunction. The present study aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and to demonstrate that neuroendocrine, personality and clinical characteristics influence neurocognitive performance in BN.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291710001303_sec_a002\"><jats:title>Method<\/jats:title><jats:p>Attention\/immediate memory, set shifting, perseveration, conditional and implicit learning were evaluated in 83 untreated female patients with BN and 77 healthy controls (HC). Cortisol and 17\u03b2-estradiol plasma levels were assessed. Cloninger's Temperament and Character Inventory \u2013 Revised (TCI-R), the Bulimic Investigation Test Edinburgh (BITE) and the Montgomery\u2013Asberg Depression Rating Scale (MADRS) were administered.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291710001303_sec_a003\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>No impairment of cognitive performance was found in subjects with BN compared with HC. Cortisol and \u2018Self-directedness\u2019 were associated with better performance on conditional learning whereas 17\u03b2-estradiol had a negative influence on this domain; \u2018Reward dependence\u2019 was associated with worse performance on implicit learning; and depressive symptomatology influenced performance on the Wisconsin Card Sorting Test (WCST) negatively.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291710001303_sec_a004\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>No cognitive impairment was found in untreated patients with BN. Neuroendocrine, personality and clinical variables do influence neurocognitive functioning and might explain discrepancies in literature findings.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291710001303","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T12:29:06Z","timestamp":1277987346000},"page":"839-848","source":"Crossref","is-referenced-by-count":26,"title":["Neurocognitive functioning in bulimia nervosa: the role of neuroendocrine, personality and clinical aspects"],"prefix":"10.1017","volume":"41","author":[{"given":"S.","family":"Galderisi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bellodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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