{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:12:17Z","timestamp":1770678737557,"version":"3.49.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T00:00:00Z","timestamp":1285113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:sec id=\"S0033291710001765_sec_a001\"><jats:title>Background<\/jats:title><jats:p>Cognitive rehabilitation has emerged as an effective treatment for addressing cognitive impairments and functional disability in schizophrenia; however, the degree to which changes in various social and non-social cognitive processes translate into improved functioning during treatment remains unclear. This research sought to identify the neurocognitive and social-cognitive mechanisms of functional improvement during a 2-year trial of cognitive enhancement therapy (CET) for early-course schizophrenia.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291710001765_sec_a002\"><jats:title>Method<\/jats:title><jats:p>Patients in the early course of schizophrenia were randomly assigned to CET (<jats:italic>n<\/jats:italic>=31) or an enriched supportive therapy control (<jats:italic>n<\/jats:italic>=27) and treated for up to 2 years. A comprehensive neurocognitive assessment battery and the Mayer\u2013Salovey\u2013Caruso Emotional Intelligence Test (MSCEIT) were completed annually, along with measures of functioning. Mediator analyses using mixed-effects growth models were conducted to examine the effects of neurocognitive and social-cognitive improvement on functional change.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291710001765_sec_a003\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Improvements over 2 years in neurocognition and the emotion management branch of the MSCEIT were found to be significantly related to improved functional outcome in early-course schizophrenia patients. Neurocognitive improvement, primarily in executive functioning, and social-cognitive change in emotion management also mediated the robust effects of CET on functioning.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291710001765_sec_a004\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Improvements in neurocognition and social cognition that result from cognitive rehabilitation are both significant mediators of functional improvement in early-course schizophrenia. Cognitive rehabilitation programs for schizophrenia may need to target deficits in both social and non-social cognition to achieve an optimal functional response.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291710001765","type":"journal-article","created":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T10:14:31Z","timestamp":1285150471000},"page":"1253-1261","source":"Crossref","is-referenced-by-count":63,"title":["Mechanisms of functional improvement in a 2-year trial of cognitive enhancement therapy for early schizophrenia"],"prefix":"10.1017","volume":"41","author":[{"given":"S. M.","family":"Eack","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Pogue-Geile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Greenwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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