{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:58:03Z","timestamp":1792144683109,"version":"4.4.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T00:00:00Z","timestamp":1300752000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec id=\"S0033291711000390_sec_a001\"><jats:title>Background<\/jats:title><jats:p>Anorexia nervosa (AN) is a serious psychiatric illness associated with significant morbidity and mortality. There is little empirical support for specific treatments and new approaches are sorely needed. This two-site study aimed to determine whether olanzapine is superior to placebo in increasing body mass index (BMI) and improving psychological symptoms in out-patients with AN.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291711000390_sec_a002\"><jats:title>Method<\/jats:title><jats:p>A total of 23 individuals with AN were randomly assigned in double-blind fashion to receive olanzapine or placebo for 8 weeks together with medication management sessions that emphasized compliance. Weight, other physical assessments and measures of psychopathology were collected.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291711000390_sec_a003\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>End-of-treatment BMI, with initial BMI as a covariate, was significantly greater in the group receiving olanzapine [<jats:italic>F<\/jats:italic>(1, 20)=6.64, <jats:italic>p<\/jats:italic>=0.018]. Psychological symptoms improved in both groups, but there were no statistically significant group differences. Of the 23 participants, 17 (74%) completed the 8-week trial. Participants tolerated the medication well with sedation being the only frequent side effect and no adverse metabolic effects were noted.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291711000390_sec_a004\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>This small study suggests that olanzapine is generally well tolerated by, and may provide more benefit than placebo for out-patients with AN. Further study is indicated to determine whether olanzapine may affect psychological symptoms in addition to BMI.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291711000390","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T08:08:02Z","timestamp":1300781282000},"page":"2177-2182","source":"Crossref","is-referenced-by-count":117,"title":["Olanzapine <i>versus<\/i> placebo for out-patients with anorexia nervosa"],"prefix":"10.1017","volume":"41","author":[{"given":"E.","family":"Attia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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