{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:31:46Z","timestamp":1783647106651,"version":"3.55.0"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec id=\"S0033291712002176_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Facial emotion perception (FEP) is a critical human skill for successful social interaction, and a substantial body of literature suggests that explicit FEP is disrupted in major depressive disorder (MDD). Prior research suggests that weakness in FEP may be an important phenomenon underlying patterns of emotion-processing challenges in MDD and the disproportionate frequency of MDD in women.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291712002176_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Women with (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) MDD, equivalent in age and education, completed a FEP task during functional magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291712002176_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The MDD group exhibited greater extents of frontal, parietal and subcortical activation compared with the control group during FEP. Activation in the inferior frontal gyrus (IFG) appeared shifted from a left &gt;right pattern observed in healthy women to a bilateral pattern in MDD women. The ratio of left to right suprathreshold IFG voxels in healthy controls was nearly 3:1, whereas in the MDD group, there was a greater percentage of suprathreshold IFG voxels bilaterally, with no leftward bias. In MDD, relatively greater activation in right IFG compared with left IFG (ratio score) was present and predicted FEP accuracy (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.56, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.004), with an inverse relationship observed between FEP and subgenual cingulate activation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212\u00a00.46, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291712002176_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>This study links, for the first time, disrupted IFG activation laterality and increased subgenual cingulate activation with deficient FEP in women with MDD, providing an avenue for imaging-to-assessment translational applications in MDD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291712002176","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T15:41:48Z","timestamp":1357659708000},"page":"1433-1445","source":"Crossref","is-referenced-by-count":31,"title":["Shifted inferior frontal laterality in women with major depressive disorder is related to emotion-processing deficits"],"prefix":"10.1017","volume":"43","author":[{"given":"E. M.","family":"Brice\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. L.","family":"Weisenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Rapport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. E.","family":"Hazlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Bieliauskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. D.","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Ransom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Brinkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Peci\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. E.","family":"Schteingart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Starkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Giordani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. C.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-K.","family":"Zubieta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Langenecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,1,8]]},"reference":[{"key":"S0033291712002176_ref27","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.115.4.705"},{"key":"S0033291712002176_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.04.031"},{"key":"S0033291712002176_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.7.597"},{"key":"S0033291712002176_ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.9.877"},{"key":"S0033291712002176_ref25","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.100.4.535"},{"key":"S0033291712002176_ref24","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0033291712002176_ref18","doi-asserted-by":"publisher","DOI":"10.1080\/15622970701624603"},{"key":"S0033291712002176_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm179"},{"key":"S0033291712002176_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.028"},{"key":"S0033291712002176_ref9","first-page":"423","article-title":"Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3\u00a0T fMR1 study","volume":"32","author":"Dannlowski","year":"2007","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"S0033291712002176_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3283294159"},{"key":"S0033291712002176_ref43","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.102.3.358"},{"key":"S0033291712002176_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000174407.09515.cc"},{"key":"S0033291712002176_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.05.034"},{"key":"S0033291712002176_ref4","unstructured":"Brett M , Anton J-L , Valabreque R , Poline J-B (2002). Region of interest analysis using an SPM toolbox. Abstract presented at the 8th International Conference on Functional Mapping of the Human Brain, Sendai, Japan."},{"key":"S0033291712002176_ref20a","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000183901.70030.82"},{"key":"S0033291712002176_ref17","volume-title":"Structured Clinical Interview for DSM\u2013IV Axis I Disorders","author":"First","year":"1996"},{"key":"S0033291712002176_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.11.004"},{"key":"S0033291712002176_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.12.009"},{"key":"S0033291712002176_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301411"},{"key":"S0033291712002176_ref20","first-page":"418","article-title":"Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies","volume":"34","author":"Fusar-Poli","year":"2009","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"S0033291712002176_ref14","volume-title":"Pictures of Facial Affect","author":"Ekman","year":"1976"},{"key":"S0033291712002176_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199910000-00002"},{"key":"S0033291712002176_ref53","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000043"},{"key":"S0033291712002176_ref41a","doi-asserted-by":"publisher","DOI":"10.1037\/a0012811"},{"key":"S0033291712002176_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.027"},{"key":"S0033291712002176_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.03.024"},{"key":"S0033291712002176_ref52","volume-title":"Using Multivariate Statistics","author":"Tabachnick","year":"2007"},{"key":"S0033291712002176_ref16a","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2009.07.010"},{"key":"S0033291712002176_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.11.017"},{"key":"S0033291712002176_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.09.032"},{"key":"S0033291712002176_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.02.019"},{"key":"S0033291712002176_ref26","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2063-07.2007"},{"key":"S0033291712002176_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.03.019"},{"key":"S0033291712002176_ref28","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108093589"},{"key":"S0033291712002176_ref57","first-page":"1","volume-title":"Women and Depression","author":"Wright","year":"2008"},{"key":"S0033291712002176_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.04.019"},{"key":"S0033291712002176_ref31","doi-asserted-by":"publisher","DOI":"10.1080\/13803390490490515720"},{"key":"S0033291712002176_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e3181923f82"},{"key":"S0033291712002176_ref10","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.64"},{"key":"S0033291712002176_ref34","first-page":"523","volume-title":"Neuropsychological Assessment of Neuropsychiatric Disorders","author":"Langenecker","year":"2009"},{"key":"S0033291712002176_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.07.006"},{"key":"S0033291712002176_ref38","doi-asserted-by":"publisher","DOI":"10.1037\/a0016944"},{"key":"S0033291712002176_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"S0033291712002176_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.12.020"},{"key":"S0033291712002176_ref45","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.65"},{"key":"S0033291712002176_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.12.011"},{"key":"S0033291712002176_ref58","doi-asserted-by":"publisher","DOI":"10.1002\/da.20502"},{"key":"S0033291712002176_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(92)90116-K"},{"key":"S0033291712002176_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000596"},{"key":"S0033291712002176_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01263-X"},{"key":"S0033291712002176_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.05.006"},{"key":"S0033291712002176_ref56","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.105.1.34"},{"key":"S0033291712002176_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.03.094"},{"key":"S0033291712002176_ref48","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.16.1.102"},{"key":"S0033291712002176_ref55","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291710002084"},{"key":"S0033291712002176_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00168-9"},{"key":"S0033291712002176_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00163-5"},{"key":"S0033291712002176_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00099-4"},{"key":"S0033291712002176_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.033"},{"key":"S0033291712002176_ref46","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.166"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291712002176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T21:24:12Z","timestamp":1556054652000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291712002176\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,8]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0033291712002176"],"URL":"https:\/\/doi.org\/10.1017\/s0033291712002176","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,8]]}}}