{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T11:36:48Z","timestamp":1794137808298,"version":"4.8.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T00:00:00Z","timestamp":1378684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec id=\"S0033291713001669_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Chromosome 22q11.2 deletion syndrome (22q11DS) is a common genetic disorder with high rates of psychosis and other psychopathologies, but few studies discuss treatment. Our aim was to characterize the prevalence and treatment of major psychiatric illnesses in a well-characterized sample of individuals with 22q11DS.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291713001669_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>This was a cross-sectional study of 112 individuals aged 8 to 45 years with a confirmed diagnosis of 22q11DS. Each participant was administered a modified Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS) and the Structured Interview for Prodromal Syndromes (SIPS). Phenotypes assessed were threshold and subthreshold psychosis, depression, mania, generalized and separation anxiety, obsessions\/compulsions, inattention\/hyperactivity and substance use. Histories of mental health care and current psychotropic treatment were obtained.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291713001669_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Psychopathology was common, with 79% of individuals meeting diagnostic criteria for a disorder at the time of assessment. Diagnoses of psychosis were made in 11% of cases, attenuated positive symptom syndrome (APS) in 21%, and 47% experienced significant subthreshold symptoms. Peak occurrence of psychosis risk was during adolescence (62% of those aged 12\u201317 years). Criteria for a mood disorder were met by 14%, for anxiety disorder 34% and for attention deficit hyperactivity disorder (ADHD) 31%. Mental health care had been received by 63% of individuals in their lifetime, but only 40% continued therapy and 39% used psychotropics. Antipsychotics were used by 42% of participants with psychosis and none of the participants with APS. Half of those at risk for psychosis were receiving no mental health care.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291713001669_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Psychopathology is common in 22q11DS but is not adequately treated or clinically followed. Particular attention should be paid to subthreshold psychotic symptoms, especially in adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291713001669","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T15:53:47Z","timestamp":1378742027000},"page":"1267-1277","source":"Crossref","is-referenced-by-count":112,"title":["Psychiatric disorders in 22q11.2 deletion syndrome are prevalent but undertreated"],"prefix":"10.1017","volume":"44","author":[{"given":"S. X.","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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