{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:52:04Z","timestamp":1789645924488,"version":"4.0.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T00:00:00Z","timestamp":1380153600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec id=\"S0033291713002353_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Maternal stress during pregnancy is associated with a modestly increased risk of fetal growth restriction and pre-eclampsia. Since placental abruption shares similar pathophysiological mechanisms and risk factors with fetal growth restriction and pre-eclampsia, we hypothesized that maternal stress may be implicated in abruption risk. We investigated the association between maternal bereavement during pregnancy and placental abruption.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291713002353_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>We studied singleton births in Denmark (1978\u20132008) and Sweden (1973\u20132006) (<jats:italic>n<\/jats:italic>\u00a0=\u00a05\u00a0103\u00a0272). In nationwide registries, we obtained data on death of women's close family members (older children, siblings, parents, and partners), abruption and potential confounders.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291713002353_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 30\u00a0312 (6\/1000) pregnancies in the cohort were diagnosed with placental abruption. Among normotensive women, death of a child the year before or during pregnancy was associated with a 54% increased odds of abruption [95% confidence interval (CI) 1.30\u20131.82]; the increased odds were restricted to women who lost a child the year before or during the first trimester in pregnancy. In the group with chronic hypertension, death of a child the year before or in the first trimester of pregnancy was associated with eight-fold increased odds of abruption (odds ratio 8.17, 95% CI 3.17\u201321.10). Death of other relatives was not associated with abruption risk.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291713002353_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Loss of a child the year before or in the first trimester of pregnancy was associated with an increased risk of abruption, especially among women with chronic hypertension. Studies are needed to investigate the effect of less severe, but more frequent, sources of stress on placental abruption risk.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291713002353","type":"journal-article","created":{"date-parts":[[2013,9,26]],"date-time":"2013-09-26T12:05:05Z","timestamp":1380197105000},"page":"1855-1866","source":"Crossref","is-referenced-by-count":13,"title":["Loss of a close family member the year before or during pregnancy and the risk of placental abruption: a cohort study from Denmark and Sweden"],"prefix":"10.1017","volume":"44","author":[{"given":"K. D.","family":"L\u00e1szl\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. V.","family":"Ananth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Obel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cnattingius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,9,26]]},"reference":[{"key":"S0033291713002353_ref3","first-page":"263","article-title":"The Danish National Hospital Register. A valuable source of data for modern health sciences","volume":"46","author":"Andersen","year":"1999","journal-title":"Danish Medical Bulletin"},{"key":"S0033291713002353_ref23","first-page":"320","article-title":"The Danish Medical Birth Registry","volume":"45","author":"Knudsen","year":"1998","journal-title":"Danish Medical Bulletin"},{"key":"S0033291713002353_ref35","unstructured":"National Board of Health and Welfare (2011). D\u00f6dsorsaker 2010 (Causes of Death 2010) (http:\/\/www.socialstyrelsen.se\/Lists\/Artikelkatalog\/Attachments\/18394\/2011-7-6.pdf). Accessed 8 February 2013."},{"key":"S0033291713002353_ref28","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199907000-00007"},{"key":"S0033291713002353_ref44","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200107000-00003"},{"key":"S0033291713002353_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws383"},{"key":"S0033291713002353_ref14","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111066"},{"key":"S0033291713002353_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31820a62ce"},{"key":"S0033291713002353_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02676-3"},{"key":"S0033291713002353_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.07.024"},{"key":"S0033291713002353_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.10.005"},{"key":"S0033291713002353_ref38","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601088406"},{"key":"S0033291713002353_ref40","unstructured":"Statistics Sweden (2006). Evalvering av utbildningsregistret (Evaluation of the Swedish Education Register) (http:\/\/www.scb.se\/statistik\/_publikationer\/BE9999_2006A01_BR_BE96ST0604.pdf). Accessed 8 February 2013."},{"key":"S0033291713002353_ref33","unstructured":"National Board of Health and Welfare (2003). The Swedish Medical Birth Register - a summary of content and quality (http:\/\/www.socialstyrelsen.se\/Lists\/Artikelkatalog\/Attachments\/10655\/2003-112-3_20031123.pdf). Accessed 8 February 2013."},{"key":"S0033291713002353_ref19","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den418"},{"key":"S0033291713002353_ref41","unstructured":"Statistics Sweden (2010). Multi-generation register 2009: a description of contents and quality (http:\/\/www.scb.se\/statistik\/_publikationer\/BE9999_2009A01_BR_BE96BR1003.pdf). Accessed 8 February 2013."},{"key":"S0033291713002353_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1996.tb14164.x"},{"key":"S0033291713002353_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.07.025"},{"key":"S0033291713002353_ref12","doi-asserted-by":"publisher","DOI":"10.3109\/10253890903349501"},{"key":"S0033291713002353_ref17","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.1.79"},{"key":"S0033291713002353_ref21","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-14078"},{"key":"S0033291713002353_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.08.006"},{"key":"S0033291713002353_ref43","unstructured":"Timmermans B (2010). The Danish integrated database for labor market research: towards demystification for the English speaking audience (http:\/\/www3.druid.dk\/wp\/20100016.pdf). Accessed 8 February 2013."},{"key":"S0033291713002353_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-001-0074-y"},{"key":"S0033291713002353_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"S0033291713002353_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318177940d"},{"key":"S0033291713002353_ref4","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1987"},{"key":"S0033291713002353_ref36","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000239439.04364.9a"},{"key":"S0033291713002353_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.03.011"},{"key":"S0033291713002353_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.01.016"},{"key":"S0033291713002353_ref39","first-page":"901","article-title":"Myometrial norepinephrine in human pregnancy. Elevated levels in various disorders leading to cesarean section","volume":"34","author":"Rydhstr\u00f6m","year":"1989","journal-title":"Journal of Reproductive Medicine"},{"key":"S0033291713002353_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/140349489001800209"},{"key":"S0033291713002353_ref31","first-page":"82","article-title":"The Danish Psychiatric Central Register","volume":"44","author":"Munk-Jorgensen","year":"1997","journal-title":"Danish Medical Bulletin"},{"key":"S0033291713002353_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(96)00018-2"},{"key":"S0033291713002353_ref25","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00550"},{"key":"S0033291713002353_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(03)00133-8"},{"key":"S0033291713002353_ref6","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701298365"},{"key":"S0033291713002353_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq127"},{"key":"S0033291713002353_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199607000-00001"},{"key":"S0033291713002353_ref18","first-page":"523","article-title":"Incidence and recurrence rate of abruptio placentae in Sweden","volume":"67","author":"K\u00e5reg\u00e5rd","year":"1986","journal-title":"Obstetrics and Gynecology"},{"key":"S0033291713002353_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.012"},{"key":"S0033291713002353_ref22","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802551795"},{"key":"S0033291713002353_ref37","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"Pedersen","year":"2006","journal-title":"Danish Medical Bulletin"},{"key":"S0033291713002353_ref34","unstructured":"National Board of Health and Welfare (2009). Kvalitet och inneh\u00e5ll i patientregistret. Utskrivningar fr\u00e5n sluttenv\u00e5rden 1964\u20132007 och bes\u00f6k i specialiserad \u00f6ppenv\u00e5rd (exclusive prim\u00e4rv\u00e5rdsbes\u00f6k) 1997\u20132007 [Quality and content of the Patient Register records. Discharges from inpatient care 1964\u20132007 and visits to specialized outpatient care (excluding primary care visits) 1997\u20132007] (http:\/\/www.socialstyrelsen.se\/Lists\/Artikelkatalog\/Attachments\/8306\/2009-125-15_200912515_rev2.pdf). Accessed 8 February 2013."}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291713002353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T19:01:10Z","timestamp":1555959670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291713002353\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,26]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0033291713002353"],"URL":"https:\/\/doi.org\/10.1017\/s0033291713002353","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,26]]}}}