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Uncontrolled studies suggest that longer initial hospitalizations that normalize weight produce better outcomes and fewer admissions than shorter hospitalizations with lower discharge weights. This study aimed to compare the effectiveness of hospitalization for weight restoration (WR) to medical stabilization (MS) in adolescent AN.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714001573_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>We performed a randomized controlled trial (RCT) with 82 adolescents, aged 12\u201318 years, with a DSM-IV diagnosis of AN and medical instability, admitted to two pediatric units in Australia. Participants were randomized to shorter hospitalization for MS or longer hospitalization for WR to 90% expected body weight (EBW) for gender, age and height, both followed by 20 sessions of out-patient, manualized family-based treatment (FBT).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714001573_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The primary outcome was the number of hospital days, following initial admission, at the 12-month follow-up. Secondary outcomes were the total number of hospital days used up to 12 months and full remission, defined as healthy weight (&gt;95% EBW) and a global Eating Disorder Examination (EDE) score within 1 standard deviation (<jats:sc>s.d.<\/jats:sc>) of published means. There was no significant difference between groups in hospital days following initial admission. There were significantly more total hospital days used and post-protocol FBT sessions in the WR group. There were no moderators of primary outcome but participants with higher eating psychopathology and compulsive features reported better clinical outcomes in the MS group.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714001573_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Outcomes are similar with hospitalizations for MS or WR when combined with FBT. Cost savings would result from combining shorter hospitalization with FBT.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291714001573","type":"journal-article","created":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T07:52:53Z","timestamp":1405324373000},"page":"415-427","source":"Crossref","is-referenced-by-count":185,"title":["A randomized controlled trial of in-patient treatment for anorexia nervosa in medically unstable adolescents"],"prefix":"10.1017","volume":"45","author":[{"given":"S.","family":"Madden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Miskovic-Wheatley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wallis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Le Grange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Rhodes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Touyz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"S0033291714001573_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20255"},{"key":"S0033291714001573_ref58","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-108X(200005)27:4<381::AID-EAT2>3.0.CO;2-U"},{"key":"S0033291714001573_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2011.11.003"},{"key":"S0033291714001573_ref9","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.6.807"},{"key":"S0033291714001573_ref43","volume-title":"Treatment Manual for Anorexia Nervosa, Second Edition: A Family-Based Approach","author":"Lock","year":"2013"},{"key":"S0033291714001573_ref28","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200006000-00005"},{"key":"S0033291714001573_ref33","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.10.877"},{"key":"S0033291714001573_ref26","volume-title":"National Efficient Cost Determination 2014\u201315","year":"2014"},{"key":"S0033291714001573_ref3","volume-title":"Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition","year":"2013"},{"key":"S0033291714001573_ref61","doi-asserted-by":"publisher","DOI":"10.1080\/j.1440-1614.2006.01758.x"},{"key":"S0033291714001573_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-1971(02)00083-0"},{"key":"S0033291714001573_ref32","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.27.2(Suppl.).S101"},{"key":"S0033291714001573_ref60","unstructured":"University Hospitals (2014). 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