{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:57:55Z","timestamp":1781528275200,"version":"3.54.1"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec id=\"S0033291714002001_sec_a1\"><jats:title>Background.<\/jats:title><jats:p>The amygdala and subgenual anterior cingulate cortex (sACC) are key brain regions for the generation of negative affect. In this longitudinal fMRI study of adolescents we investigated how amygdala\u2013sACC connectivity was correlated with negative affectivity (NA) both cross-sectionally and longitudinally, and examined its relationship to the onset of first-episode depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002001_sec_a2\"><jats:title>Method.<\/jats:title><jats:p>Fifty-six adolescents who were part of a larger longitudinal study of adolescent development were included. They had no history of mental illness at the time of their baseline scan (mean age 16.5 years) and had a follow-up scan 2 years later (mean age 18.8 years). We used resting-state functional-connectivity MRI to investigate whether cross-sectional and change measures of amygdala\u2013sACC connectivity were (i) correlated with NA and its change over time, and (ii) related to the onset of first-episode depression.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002001_sec_a3\"><jats:title>Results.<\/jats:title><jats:p>The magnitude of amygdala connectivity with sACC showed significant positive correlation with NA at both time-points. Further analysis confirmed that change in amygdala\u2013sACC connectivity between assessments was correlated with change in NA. Eight participants developed a first episode of depression between the baseline and follow-up assessments: they showed increased amygdala\u2013sACC connectivity at follow-up.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002001_sec_a4\"><jats:title>Conclusions.<\/jats:title><jats:p>Amygdala\u2013sACC connectivity is associated with NA in adolescence, with change in connectivity between these regions showing positive correlation with change in NA. Our observation that the onset of depression was associated with an increase in connectivity between the regions provides support for the neurobiological \u2018scar\u2019 hypothesis of depression.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291714002001","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T14:00:51Z","timestamp":1409148051000},"page":"1001-1009","source":"Crossref","is-referenced-by-count":66,"title":["Functional brain-imaging correlates of negative affectivity and the onset of first-episode depression"],"prefix":"10.1017","volume":"45","author":[{"given":"C. G.","family":"Davey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Whittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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