{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:34:49Z","timestamp":1771036489981,"version":"3.50.1"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec id=\"S0033291714002529_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Dysfunctional attitudes are a feature of depression that has been correlated with receptor binding abnormalities in limbic and cortical regions. We sought to investigate the functional neuroanatomy of dysfunctional attitudes in major depressive disorder (MDD) and the effects of treatment with cognitive\u2013behavioural therapy (CBT).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002529_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Participants were 16 patients with unipolar depression in an acute depressive episode (mean age 40.0 years) and 16 matched healthy controls (mean age 39.9 years). Patients were medication free and received a course of treatment with CBT. All participants underwent functional magnetic resonance imaging (fMRI) scans at baseline and at week 16, prior to the initiation of therapy and following the course of CBT for patients. During each fMRI scan, participants indicated their attributions to statements from a modified Dysfunctional Attitudes Scale (mDAS-48).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002529_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>MDD patients in an acute depressive episode endorsed a greater number of extreme responses to DAS statements, which normalized following CBT treatment. Extreme attributions were associated with greater activation in the left hippocampal region, inferior parietal lobe and precuneus in MDD patients as compared with healthy controls as a main effect of group. An interaction effect was found in the left parahippocampal region, which showed less attenuation in MDD patients at the follow-up scan relative to healthy controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002529_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Attenuation of activity in the parahippocampal region may be indicative of an improvement in dysfunctional thinking following CBT treatment in depression, while persistent engagement of regions involved in attentional processing and memory retrieval with extreme attributions reflects a trait feature of depression.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291714002529","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T10:34:50Z","timestamp":1413974090000},"page":"1425-1433","source":"Crossref","is-referenced-by-count":29,"title":["Neural effects of cognitive\u2013behavioural therapy on dysfunctional attitudes in depression"],"prefix":"10.1017","volume":"45","author":[{"given":"A.","family":"Sankar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Paszkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. P.","family":"Giampietro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H. Y.","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"S0033291714002529_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7894(01)80008-3"},{"key":"S0033291714002529_ref34","doi-asserted-by":"publisher","DOI":"10.1006\/jrpe.1994.1019"},{"key":"S0033291714002529_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/1073858404263596"},{"key":"S0033291714002529_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.12.013"},{"key":"S0033291714002529_ref43","volume-title":"Co-Planar Stereotaxic Atlas of the Human Brain: 3-D Proportional System. An Approach to Cerebral Imaging","author":"Talairach","year":"1988"},{"key":"S0033291714002529_ref27","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.12.1271"},{"key":"S0033291714002529_ref46","unstructured":"Weissman AN , Beck AT (1978). Development and validation of the dysfunctional attitude scale: a preliminary investigation. Paper presented at the annual meeting of the American Educational Research Association, Toronto, Canada (eric.ed.gov\/?id=ED167619). Accessed September 2014."},{"key":"S0033291714002529_ref17","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.110.2.215"},{"key":"S0033291714002529_ref42","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.109.4.768"},{"key":"S0033291714002529_ref30","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.9.829"},{"key":"S0033291714002529_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.10.028"},{"key":"S0033291714002529_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1113"},{"key":"S0033291714002529_ref13","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version, User's Guide","author":"First","year":"1997"},{"key":"S0033291714002529_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2345"},{"key":"S0033291714002529_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.03.003"},{"key":"S0033291714002529_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20053"},{"key":"S0033291714002529_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(00)00093-3"},{"key":"S0033291714002529_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl004"},{"key":"S0033291714002529_ref18","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0033291714002529_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.06.021"},{"key":"S0033291714002529_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.05.019"},{"key":"S0033291714002529_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/BF01173007"},{"key":"S0033291714002529_ref24","doi-asserted-by":"publisher","DOI":"10.1891\/0889-8391.26.4.381"},{"key":"S0033291714002529_ref25","first-page":"521","article-title":"Neural correlates of treatment outcome in major depression","volume":"14","author":"Lisiecka","year":"2011","journal-title":"International Journal of Neuro-Psychopharmacology"},{"key":"S0033291714002529_ref48","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nst009"},{"key":"S0033291714002529_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(02)00214-8"},{"key":"S0033291714002529_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.10.012"},{"key":"S0033291714002529_ref21","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.5.778"},{"key":"S0033291714002529_ref22","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.6.899"},{"key":"S0033291714002529_ref28","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.90"},{"key":"S0033291714002529_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00108-7"},{"key":"S0033291714002529_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.04.033"},{"key":"S0033291714002529_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.09.032"},{"key":"S0033291714002529_ref39","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.7.749"},{"key":"S0033291714002529_ref10","first-page":"3","volume-title":"Handbook of Cognitive Behavioral Therapies","author":"Dobson","year":"2001"},{"key":"S0033291714002529_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbtep.2009.10.003"},{"key":"S0033291714002529_ref41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812686106"},{"key":"S0033291714002529_ref1","volume-title":"Depression: Clinical, Experimental, and Theoretical Aspects","author":"Beck","year":"1967"},{"key":"S0033291714002529_ref38","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acr048"},{"key":"S0033291714002529_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.09.007"},{"key":"S0033291714002529_ref23","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1997.0267"},{"key":"S0033291714002529_ref3","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.112.3.488"},{"key":"S0033291714002529_ref2","volume-title":"Cognitive Therapy for Depression","author":"Beck","year":"1979"},{"key":"S0033291714002529_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.09.018"},{"key":"S0033291714002529_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465802003107"},{"key":"S0033291714002529_ref35","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0777"},{"key":"S0033291714002529_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20500"},{"key":"S0033291714002529_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.1.34"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291714002529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T01:22:54Z","timestamp":1555809774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291714002529\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S0033291714002529"],"URL":"https:\/\/doi.org\/10.1017\/s0033291714002529","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}