{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T19:12:25Z","timestamp":1785611545194,"version":"3.56.0"},"reference-count":55,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec id=\"S0033291714002657_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Severe stress in social situations is a core symptom of social anxiety disorder (SAD). Connectivity between the amygdala and cortical regions is thought to be important for emotion regulation, a function that is compromised in SAD. However, it has never been tested if and how this connectivity pattern changes under conditions of stress-inducing social evaluative threat. Here we investigate changes in cortical-amygdala coupling in SAD during the anticipation of giving a public speech.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002657_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>Twenty individuals with SAD and age-, gender- and education-matched controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) participated in this study. During the functional magnetic resonance imaging (fMRI) session, participants underwent three \u2018resting-state\u2019 fMRI scans: one before, one during, and one after the anticipation of giving a public speech. Functional connectivity between cortical emotion regulation regions and the amygdala was investigated.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002657_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Compared to controls, SAD participants showed reduced functional integration between cortical emotion regulation regions and the amygdala during the public speech anticipation. Moreover, in SAD participants cortical-amygdala connectivity changes correlated with social anxiety symptom severity.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002657_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>The distinctive pattern of cortical-amygdala connectivity suggests less effective cortical-subcortical communication during social stress-provoking situations in SAD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291714002657","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T07:21:29Z","timestamp":1416986489000},"page":"1521-1529","source":"Crossref","is-referenced-by-count":33,"title":["Altered cortical-amygdala coupling in social anxiety disorder during the anticipation of giving a public speech"],"prefix":"10.1017","volume":"45","author":[{"given":"H. R.","family":"Cremers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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