{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:24:28Z","timestamp":1768451068192,"version":"3.49.0"},"reference-count":62,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:00:00Z","timestamp":1415923200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec id=\"S0033291714002724_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Although risk for psychosis in velocardiofacial (22q11.2 deletion) syndrome (VCFS) is well established, the cognitive and familial factors that moderate that risk are poorly understood.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002724_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>A total of 75 youth with VCFS were assessed at three time points, at 3-year intervals. Time 1 (T1) psychiatric risk was assessed with the Behavior Assessment System for Children (BASC). Data reduction of BASC scores yielded avoidance\u2013anxiety and dysregulation factors. Time 2 (T2) neuropsychological and family function and time 3 (T3) prodromal\/overt psychosis were assessed. Poisson regression models tested associations between T3 positive prodromal symptoms\/overt psychosis and T1 psychiatric risk, T2 cognitive and familial factors, and their interactions.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002724_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>T1 avoidance\u2013anxiety ratings predicted T3 prodromal\/overt psychosis. T2 verbal learning scores moderated this association, such that individuals with low avoidance\u2013anxiety scores and stronger verbal learning skills were the least likely to demonstrate prodromal\/overt psychosis at T3. Low scores on a T2 visual vigilance task also predicted T3 prodromal\/overt psychosis, independently of the effect of T1 avoidance\u2013anxiety scores. T1 dysregulation scores did not predict T3 prodromal\/overt psychosis in a linear manner. Instead, the association between dysregulation and prodromal\/overt psychosis was amplified by T2 levels of family organization, such that individuals with low dysregulation scores and low family organization scores were the most likely to exhibit T3 prodromal\/overt psychosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291714002724_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Significant moderators of psychiatric risk in VCFS include verbal learning skills as well as levels of family organization, carrying implications for early identification and preventative treatment of youth with VCFS at highest risk for psychosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291714002724","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T11:04:31Z","timestamp":1415963071000},"page":"1629-1639","source":"Crossref","is-referenced-by-count":20,"title":["Neurocognitive and familial moderators of psychiatric risk in velocardiofacial (22q11.2 deletion) syndrome: a longitudinal study"],"prefix":"10.1017","volume":"45","author":[{"given":"W. 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