{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:39:55Z","timestamp":1790372395330,"version":"4.1.0"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"16","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec id=\"S0033291715001385_sec_a1\">\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Recent evidence suggests that postpartum psychiatric episodes may share similar etiological mechanisms with immune-related disorders. Pre-eclampsia is one of the most prevalent immune-related disorders of pregnancy. Multiple clinical features are shared between pre-eclampsia and postpartum psychiatric disorders, most prominently a strong link to first pregnancies. Therefore, we aimed to study if pre-eclampsia is a risk factor for first-onset postpartum psychiatric episodes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291715001385_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Method.<\/jats:title>\n                    <jats:p>We conducted a cohort study using the Danish population registry, with a total of 400 717 primiparous women with a singleton delivery between 1995 and 2011. First-lifetime childbirth was the main exposure variable and the outcome of interest was first-onset postpartum psychiatric episodes. The main outcome measures were monthly incidence rate ratios (IRRs), with the period 11\u201312 months after birth as the reference category. Adjustments were made for age, calendar period, reproductive history, and perinatal maternal health including somatic and obstetric co-morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291715001385_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>Primiparous women were at particularly high risk of first-onset psychiatric episodes during the first month postpartum [IRR 2.93, 95% confidence interval (CI) 2.53\u20133.40] and pre-eclampsia added to that risk (IRR 4.21, 95% CI 2.89\u20136.13). Having both pre-eclampsia and a somatic co-morbidity resulted in the highest risk of psychiatric episodes during the 3-month period after childbirth (IRR 4.81, 95% CI 2.72\u20138.50).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291715001385_sec_a4\" sec-type=\"conclusion\">\n                    <jats:title>Conclusions.<\/jats:title>\n                    <jats:p>We confirmed an association between pre-eclampsia and postpartum psychiatric episodes. The possible explanations for this association, which are not mutually exclusive, include the psychological impact of a serious medical condition such as pre-eclampsia and the neurobiological impact of pre-eclampsia-related vascular pathology and inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291715001385","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T05:19:10Z","timestamp":1438751950000},"page":"3481-3489","source":"Crossref","is-referenced-by-count":94,"title":["Pre-eclampsia and first-onset postpartum psychiatric episodes: a Danish population-based cohort study"],"prefix":"10.1017","volume":"45","author":[{"given":"V.","family":"Bergink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. M. W.","family":"Johannsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Meltzer-Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Munk-Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"S0033291715001385_ref25","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.7.1099"},{"key":"S0033291715001385_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.09.002"},{"key":"S0033291715001385_ref44","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13051"},{"key":"S0033291715001385_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.11.007"},{"key":"S0033291715001385_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(03)00034-8"},{"key":"S0033291715001385_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2006.06.009"},{"key":"S0033291715001385_ref32","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2008.528"},{"key":"S0033291715001385_ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390501"},{"key":"S0033291715001385_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61278-2"},{"key":"S0033291715001385_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken157"},{"key":"S0033291715001385_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2013.05.003"},{"key":"S0033291715001385_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61276-9"},{"key":"S0033291715001385_ref2","first-page":"263","article-title":"The Danish National Hospital Register. A valuable source of data for modern health sciences","volume":"46","author":"Andersen","year":"1999","journal-title":"Danish Medical Bulletin"},{"key":"S0033291715001385_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.09.034"},{"key":"S0033291715001385_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2007.04.002"},{"key":"S0033291715001385_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.158931"},{"key":"S0033291715001385_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.11.006"},{"key":"S0033291715001385_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12175"},{"key":"S0033291715001385_ref45","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.46"},{"key":"S0033291715001385_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-9589(01)00180-1"},{"key":"S0033291715001385_ref46","volume-title":"WHO ICD-10: Psykiske lidelser og adf\u00e6rdsm\u00e6ssige forstyrrelser. Klassifikation og diagnostiske kriterier (WHO ICD-10: Mental and Behavioural Disorders. Classification and Diagnostic Criteria)","year":"1994"},{"key":"S0033291715001385_ref3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14101332"},{"key":"S0033291715001385_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61277-0"},{"key":"S0033291715001385_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"S0033291715001385_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12145"},{"key":"S0033291715001385_ref35","first-page":"230","article-title":"Hormonal basis of mood and postpartum disorders","volume":"3","author":"Parry","year":"2003","journal-title":"Current Women's Health Reports Journal"},{"key":"S0033291715001385_ref22","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2584"},{"key":"S0033291715001385_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2013.03.019"},{"key":"S0033291715001385_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.09.037"},{"key":"S0033291715001385_ref30","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810395825"},{"key":"S0033291715001385_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-014-0428-5"},{"key":"S0033291715001385_ref9","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780192621269.001.0001","volume-title":"Motherhood and Mental Health","author":"Brockington","year":"1996"},{"key":"S0033291715001385_ref33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.21.2582"},{"key":"S0033291715001385_ref7","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.10m06648"},{"key":"S0033291715001385_ref26","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.150.5.662"},{"key":"S0033291715001385_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2011.02.003"},{"key":"S0033291715001385_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-003-0024-6"},{"key":"S0033291715001385_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"S0033291715001385_ref10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jlb.63.3.281","article-title":"The effects of pregnancy on autoimmune diseases","volume":"63","author":"Buyon","year":"1998","journal-title":"Journal of Leukocyte Biology"},{"key":"S0033291715001385_ref29","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"S0033291715001385_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.014"},{"key":"S0033291715001385_ref36","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"S0033291715001385_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.05.018"},{"key":"S0033291715001385_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0004867414564698"},{"key":"S0033291715001385_ref20","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.168.6.739"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291715001385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T07:11:58Z","timestamp":1718003518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291715001385\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":45,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0033291715001385"],"URL":"https:\/\/doi.org\/10.1017\/s0033291715001385","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}