{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:46:38Z","timestamp":1792097198185,"version":"4.4.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"16","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec id=\"S0033291716002002_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Anorexia nervosa (AN) is a serious illness leading to substantial morbidity and mortality. The treatment of AN very often is protracted; repeated hospitalizations and lost productivity generate substantial economic costs in the health care system. Therefore, this study aimed to determine the differential cost-effectiveness of out-patient focal psychodynamic psychotherapy (FPT), enhanced cognitive\u2013behavioural therapy (CBT-E), and optimized treatment as usual (TAU-O) in the treatment of adult women with AN.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716002002_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>The analysis was conducted alongside the randomized controlled Anorexia Nervosa Treatment of OutPatients (ANTOP) study. Cost-effectiveness was determined using direct costs per recovery at 22 months post-randomization (<jats:italic>n<\/jats:italic> = 156). Unadjusted incremental cost-effectiveness ratios (ICERs) were calculated. To derive cost-effectiveness acceptability curves (CEACs) adjusted net-benefit regressions were applied assuming different values for the maximum willingness to pay (WTP) per additional recovery. Cost\u2013utility and assumptions underlying the base case were investigated in exploratory analyses.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716002002_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Costs of in-patient treatment and the percentage of patients who required in-patient treatment were considerably lower in both intervention groups. The unadjusted ICERs indicated FPT and CBT-E to be dominant compared with TAU-O. Moreover, FPT was dominant compared with CBT-E. CEACs showed that the probability for cost-effectiveness of FTP compared with TAU-O and CBT-E was \u2a7e95% if the WTP per recovery was \u2a7e\u20ac9825 and \u2a7e\u20ac24 550, respectively. Comparing CBT-E with TAU-O, the probability of being cost-effective remained &lt;90% for all WTPs. The exploratory analyses showed similar but less pronounced trends.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716002002_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Depending on the WTP, FPT proved cost-effective in the treatment of adult AN.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291716002002","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T07:34:13Z","timestamp":1473406453000},"page":"3291-3301","source":"Crossref","is-referenced-by-count":34,"title":["Cost-effectiveness of focal psychodynamic therapy and enhanced cognitive\u2013behavioural therapy in out-patients with anorexia 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