{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:24:59Z","timestamp":1790745899489,"version":"4.1.0"},"reference-count":93,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec id=\"S0033291716002634_sec_a1\"><jats:title>Background<\/jats:title><jats:p>There is an ongoing debate whether transdiagnostic neural mechanisms are shared by different anxiety-related disorders or whether different disorders show distinct neural correlates. To investigate this issue, studies controlling for design and stimuli across multiple anxiety-related disorders are needed.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716002634_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>The present functional magnetic resonance imaging study investigated neural correlates of visual disorder-related threat processing across unmedicated patients suffering from panic disorder (<jats:italic>n<\/jats:italic>= 20), social anxiety disorder (<jats:italic>n<\/jats:italic>= 20), dental phobia (<jats:italic>n<\/jats:italic>= 16) and post-traumatic stress disorder (<jats:italic>n<\/jats:italic>= 11) relative to healthy controls (HC;<jats:italic>n<\/jats:italic>= 67). Each patient group and the corresponding HC group saw a tailor-made picture set with 50 disorder-related and 50 neutral scenes.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716002634_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Across all patients, increased activation to disorder-related<jats:italic>v<\/jats:italic>. neutral scenes was found in subregions of the bilateral amygdala. In addition, activation of the lateral amygdala to disorder-related<jats:italic>v<\/jats:italic>. neutral scenes correlated positively with subjective anxiety ratings of scenes across patients. Furthermore, whole-brain analysis revealed increased responses to disorder-related threat across the four disorders in middle, medial and superior frontal regions, (para-)limbic regions, such as the insula and thalamus, as well as in the brainstem and occipital lobe. We found no disorder-specific brain responses.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716002634_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that pathologically heightened lateral amygdala activation is linked to experienced anxiety across anxiety disorders and trauma- and stressor-related disorders. Furthermore, the transdiagnostically shared activation network points to a common neural basis of abnormal responses to disorder-related threat stimuli across the four investigated disorders.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291716002634","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T10:43:44Z","timestamp":1479725024000},"page":"730-743","source":"Crossref","is-referenced-by-count":44,"title":["Transdiagnostic brain responses to disorder-related threat across four psychiatric disorders"],"prefix":"10.1017","volume":"47","author":[{"given":"K.","family":"Feldker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Y.","family":"Heitmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Neumeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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