{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:30:27Z","timestamp":1790483427675,"version":"4.1.0"},"reference-count":67,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec id=\"S0033291716003263_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716003263_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716003263_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9\u20132.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6\u201320.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291716003263_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291716003263","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T02:48:11Z","timestamp":1483930091000},"page":"1230-1245","source":"Crossref","is-referenced-by-count":131,"title":["The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries"],"prefix":"10.1017","volume":"47","author":[{"given":"J. J.","family":"McGrath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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