{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:47:11Z","timestamp":1770450431715,"version":"3.49.0"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec id=\"S0033291717000332_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Attention-deficit\/hyperactivity disorder (ADHD) is characterized by problems in regulating attention and in suppressing disruptive motor activity, i.e. hyperactivity and impulsivity. We recently found evidence that aberrant distribution of posterior \u03b1 band oscillations (8\u201312 Hz) is associated with attentional problems in ADHD. The sensorimotor cortex also produces strong 8\u201312 Hz band oscillations, namely the \u03bc rhythm, and is thought to have a similar inhibitory function. Here, we now investigate whether problems in distributing \u03b1 band oscillations in ADHD generalize to the \u03bc rhythm in the sensorimotor domain.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717000332_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>In a group of adult ADHD (<jats:italic>n<\/jats:italic> = 17) and healthy control subjects (<jats:italic>n<\/jats:italic> = 18; aged 21\u201340 years) oscillatory brain activity was recorded using magnetoencephalography during a visuo-spatial attention task. Subjects had to anticipate a target with unpredictable timing and respond by pressing a button.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717000332_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Preparing a motor response, the ADHD group failed to increase hemispheric \u03bc lateralization with relatively higher \u03bc power in sensorimotor regions not engaged in the task, as the controls did (<jats:italic>F<\/jats:italic><jats:sub>1,33<\/jats:sub> = 8.70, <jats:italic>p<\/jats:italic> = 0.006). Moreover, the ADHD group pre-response \u03bc lateralization not only correlated positively with accuracy (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.64, <jats:italic>p<\/jats:italic> = 0.0052) and negatively with intra-individual reaction time variability (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = \u22120.52, <jats:italic>p<\/jats:italic> = 0.033), but it also correlated negatively with the score on an ADHD rating scale (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = \u22120.53, <jats:italic>p<\/jats:italic> = 0.028).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717000332_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>We suggest that ADHD is associated with an inability to sufficiently inhibit task-irrelevant sensorimotor areas by means of modulating \u03bc oscillatory activity. This could explain disruptive motor activity in ADHD. These results provide further evidence that impaired modulation of \u03b1 band oscillations is involved in the pathogenesis of ADHD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291717000332","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T05:10:49Z","timestamp":1489468249000},"page":"1947-1956","source":"Crossref","is-referenced-by-count":24,"title":["Diminished modulation of preparatory sensorimotor mu rhythm predicts attention-deficit\/hyperactivity disorder severity"],"prefix":"10.1017","volume":"47","author":[{"given":"N.","family":"ter 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