{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:35:36Z","timestamp":1791916536417,"version":"4.3.4"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec id=\"S0033291717000575_sec_a1\"><jats:title>Background<\/jats:title><jats:p>The objective of this study was to determine whether <jats:italic>hatha<\/jats:italic> yoga is an efficacious adjunctive intervention for individuals with continued depressive symptoms despite antidepressant treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717000575_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>We conducted a randomized controlled trial of weekly yoga classes (<jats:italic>n<\/jats:italic> = 63) <jats:italic>v.<\/jats:italic> health education classes (Healthy Living Workshop; HLW; <jats:italic>n<\/jats:italic> = 59) in individuals with elevated depression symptoms and antidepressant medication use. HLW served as an attention-control group. The intervention period was 10 weeks, with follow-up assessments 3 and 6 months afterwards. The primary outcome was depression symptom severity assessed by blind rater at 10 weeks. Secondary outcomes included depression symptoms over the entire intervention and follow-up periods, social and role functioning, general health perceptions, pain, and physical functioning.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717000575_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>At 10 weeks, we did not find a statistically significant difference between groups in depression symptoms (<jats:italic>b<\/jats:italic> = \u22120.82, <jats:sc>s.e.<\/jats:sc> = 0.88, <jats:italic>p<\/jats:italic> = 0.36). However, over the entire intervention and follow-up period, when controlling for baseline, yoga participants showed lower levels of depression than HLW participants (<jats:italic>b<\/jats:italic> = \u22121.38, <jats:sc>s.e.<\/jats:sc> = 0.57, <jats:italic>p<\/jats:italic> = 0.02). At 6-month follow-up, 51% of yoga participants demonstrated a response (\u2a7e50% reduction in depression symptoms) compared with 31% of HLW participants (odds ratio = 2.31; <jats:italic>p<\/jats:italic> = 0.04). Yoga participants showed significantly better social and role functioning and general health perceptions over time.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717000575_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Although we did not see a difference in depression symptoms at the end of the intervention period, yoga participants showed fewer depression symptoms over the entire follow-up period. Benefits of yoga may accumulate over time.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291717000575","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T06:17:20Z","timestamp":1491459440000},"page":"2130-2142","source":"Crossref","is-referenced-by-count":58,"title":["Adjunctive yoga <i>v.<\/i> health education for persistent major depression: a randomized controlled trial"],"prefix":"10.1017","volume":"47","author":[{"given":"L. A.","family":"Uebelacker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Tremont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. T.","family":"Gillette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Epstein-Lubow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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