{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:17:23Z","timestamp":1784575043243,"version":"3.55.0"},"reference-count":118,"publisher":"Cambridge University Press (CUP)","issue":"14","license":[{"start":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T00:00:00Z","timestamp":1492992000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec id=\"S0033291717001088_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common\/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717001088_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Age and IQ-matched boys with ASD (<jats:italic>N<\/jats:italic>= 20), with OCD (<jats:italic>N<\/jats:italic>= 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717001088_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Boys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial\/lateral orbitofrontal cortex extending into medial\/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate\/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717001088_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>This first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291717001088","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T09:07:31Z","timestamp":1493024851000},"page":"2513-2527","source":"Crossref","is-referenced-by-count":46,"title":["Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder"],"prefix":"10.1017","volume":"47","author":[{"given":"C. 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