{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:17:44Z","timestamp":1794107864508,"version":"4.8.0"},"reference-count":82,"publisher":"Cambridge University Press (CUP)","issue":"15","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec id=\"S0033291717001192_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Panic disorder (PD) patients are constantly concerned about future panic attacks and exhibit general hypersensitivity to unpredictable threat. We aimed to reveal phasic and sustained brain responses and functional connectivity of the amygdala and the bed nucleus of the stria terminalis (BNST) during threat anticipation in PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291717001192_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using functional magnetic resonance imaging (fMRI), we investigated 17 PD patients and 19 healthy controls (HC) during anticipation of temporally unpredictable aversive and neutral sounds. We used a phasic and sustained analysis model to disentangle temporally dissociable brain activations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291717001192_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PD patients compared with HC showed phasic amygdala and sustained BNST responses during anticipation of aversive\n                      <jats:italic>v<\/jats:italic>\n                      . neutral stimuli. Furthermore, increased phasic activation was observed in anterior cingulate cortex (ACC), insula and prefrontal cortex (PFC). Insula and PFC also showed sustained activation. Functional connectivity analyses revealed partly distinct phasic and sustained networks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291717001192_sec_a4\" sec-type=\"conclusion\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrate a role for the BNST during unpredictable threat anticipation in PD and provide first evidence for dissociation between phasic amygdala and sustained BNST activation and their functional connectivity. In line with a hypersensitivity to uncertainty in PD, our results suggest time-dependent involvement of brain regions related to fear and anxiety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291717001192","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T06:05:09Z","timestamp":1494309909000},"page":"2675-2688","source":"Crossref","is-referenced-by-count":61,"title":["Distinct phasic and sustained brain responses and connectivity of amygdala and bed nucleus of the stria terminalis during threat anticipation in panic disorder"],"prefix":"10.1017","volume":"47","author":[{"given":"L.","family":"Brinkmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Buff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Feldker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Tupak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P. I.","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Straube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"S0033291717001192_ref37","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07101581"},{"key":"S0033291717001192_ref23","first-page":"115","article-title":"Neural circuits in anxiety and stress disorders: A focused review","volume":"11","author":"Duval","year":"2015","journal-title":"Therapeutics and Clinical Risk Management"},{"key":"S0033291717001192_ref45","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.4.415"},{"key":"S0033291717001192_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.05.013"},{"key":"S0033291717001192_ref52","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp052"},{"key":"S0033291717001192_ref66","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(86)90143-9"},{"key":"S0033291717001192_ref9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1123721"},{"key":"S0033291717001192_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(91)90073-C"},{"key":"S0033291717001192_ref80","first-page":"68","article-title":"SKID I. Strukturiertes Klinisches Interview f\u00fcr DSM-IV. Achse I: Psychische St\u00f6rungen. Interviewheft und Beurteilungsheft. Eine deutschsprachige, erweiterte Bearbeitung des amerikanischen Originalversion des SKID I","volume":"28","author":"Wittchen","year":"1997","journal-title":"Zeitschrift f\u00fcr klinische Psychologie und Psychotherapie"},{"key":"S0033291717001192_ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2005.07.009"},{"key":"S0033291717001192_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.057"},{"key":"S0033291717001192_ref38","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3524"},{"key":"S0033291717001192_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.03.002"},{"key":"S0033291717001192_ref55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050120"},{"key":"S0033291717001192_ref47","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0821-12.2012"},{"key":"S0033291717001192_ref50","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.1"},{"key":"S0033291717001192_ref34","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.493"},{"key":"S0033291717001192_ref24","author":"Ehlers","year":"1993","journal-title":"Fragebogen zu k\u00f6rperbezogenen \u00c4ngsten, Kognitionen und Vermeidung"},{"key":"S0033291717001192_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.02.002"},{"key":"S0033291717001192_ref67","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp155"},{"key":"S0033291717001192_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000812"},{"key":"S0033291717001192_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23513"},{"key":"S0033291717001192_ref63","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.108.3.483"},{"key":"S0033291717001192_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.185"},{"key":"S0033291717001192_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.84"},{"key":"S0033291717001192_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.07.026"},{"key":"S0033291717001192_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq017"},{"key":"S0033291717001192_ref30","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330508"},{"key":"S0033291717001192_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.03.020"},{"key":"S0033291717001192_ref64","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2317"},{"key":"S0033291717001192_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2009_5"},{"key":"S0033291717001192_ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.002"},{"key":"S0033291717001192_ref8","volume-title":"Manual for the Beck-Depression-Inventory-II","author":"Beck","year":"1996"},{"key":"S0033291717001192_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2555"},{"key":"S0033291717001192_ref46","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-2-20"},{"key":"S0033291717001192_ref49","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20345"},{"key":"S0033291717001192_ref19","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.109"},{"key":"S0033291717001192_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.11.004"},{"key":"S0033291717001192_ref32","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20249"},{"key":"S0033291717001192_ref39","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs175"},{"key":"S0033291717001192_ref57","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1579-14.2014"},{"key":"S0033291717001192_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4044"},{"key":"S0033291717001192_ref35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1176\/ajp.146.2.148","article-title":"A neuroanatomical hypothesis for panic disorder","volume":"146","author":"Gorman","year":"1989","journal-title":"American Journal of Psychiatry"},{"key":"S0033291717001192_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00169-1"},{"key":"S0033291717001192_ref11","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.108.1.4"},{"key":"S0033291717001192_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0248-y"},{"key":"S0033291717001192_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.005"},{"key":"S0033291717001192_ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.11.013"},{"key":"S0033291717001192_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.08.014"},{"key":"S0033291717001192_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7916(94)90063-9"},{"key":"S0033291717001192_ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2010.09.010"},{"key":"S0033291717001192_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01355-0"},{"key":"S0033291717001192_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.09.025"},{"key":"S0033291717001192_ref33","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-4-9"},{"key":"S0033291717001192_ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"S0033291717001192_ref54","volume-title":"Atlas of the Human Brain","author":"Mai","year":"1997"},{"key":"S0033291717001192_ref3","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"S0033291717001192_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0811-1"},{"key":"S0033291717001192_ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-008-0077-9"},{"key":"S0033291717001192_ref62","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.88"},{"key":"S0033291717001192_ref13","volume-title":"International Affective Digitized Sounds (IADS): Stimuli, Instruction Manual and Affective Ratings (Tech. Rep. No. B-2)","author":"Bradley","year":"1999"},{"key":"S0033291717001192_ref43","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23088"},{"key":"S0033291717001192_ref7","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.5.647"},{"key":"S0033291717001192_ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602413113"},{"key":"S0033291717001192_ref59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009076107"},{"key":"S0033291717001192_ref36","first-page":"214","article-title":"What fMRI can tell us about panic disorder: Bridging the gap between neurobiology and psychotherapy","volume":"36","author":"Grambal","year":"2015","journal-title":"Neuroendocrinology Letters"},{"key":"S0033291717001192_ref82","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-010-0167-1"},{"key":"S0033291717001192_ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2009.05.001"},{"key":"S0033291717001192_ref74","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22899"},{"key":"S0033291717001192_ref73","volume-title":"Co-Planar Stereotactic Atlas of the Human Brain. 3-Dimensional Proportional System: An Approach to Cerebral Imaging","author":"Talairach","year":"1988"},{"key":"S0033291717001192_ref61","doi-asserted-by":"publisher","DOI":"10.1002\/da.22382"},{"key":"S0033291717001192_ref76","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"S0033291717001192_ref81","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713003085"},{"key":"S0033291717001192_ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.007"},{"key":"S0033291717001192_ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.06.023"},{"key":"S0033291717001192_ref70","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr373"},{"key":"S0033291717001192_ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.06.022"},{"key":"S0033291717001192_ref6","volume-title":"Panik und Agoraphobie-Skala (PAS). Handanweisung","author":"Bandelow","year":"1997"},{"key":"S0033291717001192_ref42","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465812000057"},{"key":"S0033291717001192_ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.04.002"},{"key":"S0033291717001192_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.017"},{"key":"S0033291717001192_ref53","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.12111484"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291717001192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T16:41:38Z","timestamp":1555432898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291717001192\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,9]]},"references-count":82,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0033291717001192"],"URL":"https:\/\/doi.org\/10.1017\/s0033291717001192","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,9]]}}}