{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:11:50Z","timestamp":1785553910219,"version":"3.56.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec id=\"S0033291717002148_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Previous studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717002148_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>The relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women. Polygenic risk scores (PRSs) were generated using European discovery samples and tested in the China, Oxford, and VCU Experimental Research on Genetic Epidemiology [CONVERGE (maximum<jats:italic>N<\/jats:italic>= 10 502)], a sample ascertained for recurrent MDD. Genetic correlations between discovery phenotypes and MDD were also assessed. In addition, within-case characteristics were examined.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717002148_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>European-based polygenic risk for several major psychiatric disorder phenotypes was significantly associated with the MDD case status in CONVERGE. Risk for clinically significant indicators (neuroticism and subjective well-being) was also associated with case\u2013control status. The variance accounted for by PRS for both psychopathology and for well-being was similar to estimates reported for within-ethnicity comparisons in European samples. However, European-based PRS were largely unassociated with CONVERGE family history, clinical characteristics, or comorbidity.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717002148_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>The shared genetic liability across severe forms of psychopathology is largely consistent across European and Han Chinese ethnicities, with little attenuation of genetic signal relative to within-ethnicity analyses. The overall absence of associations between PRS for other disorders and within-MDD variation suggests that clinical characteristics of MDD may arise due to contributions from ethnicity-specific factors and\/or pathoplasticity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291717002148","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T08:08:58Z","timestamp":1507018138000},"page":"777-789","source":"Crossref","is-referenced-by-count":10,"title":["Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women"],"prefix":"10.1017","volume":"48","author":[{"given":"A. C.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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