{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:31:12Z","timestamp":1789957872708,"version":"4.0.1"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"14","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291717003956_sec_a1\"><jats:title>Background<\/jats:title><jats:p>The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the neuropsychiatric symptoms and cognitive profile of MCI with Lewy bodies (MCI-LB) with Alzheimer's disease MCI (MCI-AD).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717003956_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Participants were \u2a7e60 years old with MCI. Each had a thorough clinical and neuropsychological assessment and 2\u03b2-carbomethoxy-3\u03b2-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT). MCI-LB was diagnosed if two or more diagnostic features of dementia with Lewy bodies were present (visual hallucinations, cognitive fluctuations, motor parkinsonism, rapid eye movement sleep behaviour disorder or positive FP-CIT SPECT). A Lewy body Neuropsychiatric Supportive Symptom Count (LBNSSC) was calculated based on the presence or absence of the supportive neuropsychiatric symptoms defined by the 2017 DLB diagnostic criteria: non-visual hallucinations, delusions, anxiety, depression and apathy.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717003956_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>MCI-LB (<jats:italic>n<\/jats:italic> = 41) had a higher LBNSSC than MCI-AD (<jats:italic>n<\/jats:italic> = 24; 1.8 \u00b1 1.1 <jats:italic>v.<\/jats:italic> 0.7 \u00b1 0.9, <jats:italic>p<\/jats:italic> = 0.001). 67% of MCI-LB had two or more of those symptoms, compared with 16% of MCI-AD (Likelihood ratio = 4.2, <jats:italic>p<\/jats:italic> &lt; 0.001). MCI-LB subjects scored lower on tests of attention, visuospatial function and verbal fluency. However, cognitive test scores alone did not accurately differentiate MCI-LB from MCI-AD.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291717003956_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>MCI-LB is associated with neuropsychiatric symptoms and a cognitive profile similar to established DLB. This supports the concept of identifying MCI-LB based on the presence of core diagnostic features of DLB and abnormal FP-CIT SPECT imaging. The presence of supportive neuropsychiatric clinical features identified in the 2017 DLB diagnostic criteria was helpful in differentiating between MCI-LB and MCI-AD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291717003956","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T07:46:58Z","timestamp":1516780018000},"page":"2384-2390","source":"Crossref","is-referenced-by-count":91,"title":["Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies"],"prefix":"10.1017","volume":"48","author":[{"given":"Paul C","family":"Donaghy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Paul","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J","family":"Colloby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Petrides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian G","family":"McKeith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"S0033291717003956_ref11","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002028"},{"key":"S0033291717003956_ref27","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.3.252"},{"key":"S0033291717003956_ref18","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161089"},{"key":"S0033291717003956_ref20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003512"},{"key":"S0033291717003956_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200005)15:3<503::AID-MDS1013>3.0.CO;2-V"},{"key":"S0033291717003956_ref28","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22340"},{"key":"S0033291717003956_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.12.007"},{"key":"S0033291717003956_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.072"},{"key":"S0033291717003956_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714000816"},{"key":"S0033291717003956_ref4","doi-asserted-by":"crossref","unstructured":"Boeve BF , Molano JR , Ferman TJ , Smith GE , Lin S-C , Bieniek K (2011) Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. 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