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Little is known about the extent to which ASD and OCD have common versus distinct neural correlates of compulsivity. Previous research points to potentially common dysfunction in frontostriatal connectivity, but direct comparisons in one study are lacking. Here, we assessed frontostriatal resting-state functional connectivity in youth with ASD or OCD, and healthy controls. In addition, we applied a cross-disorder approach to examine whether repetitive behaviour across ASD and OCD has common neural substrates.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291718003136_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A sample of 78 children and adolescents aged 8\u201316 years was used (ASD <jats:italic>n<\/jats:italic> = 24; OCD <jats:italic>n<\/jats:italic> = 25; healthy controls <jats:italic>n<\/jats:italic> = 29), originating from the multicentre study COMPULS. We tested whether diagnostic group, repetitive behaviour (measured with the Repetitive Behavior Scale-Revised) or their interaction was associated with resting-state functional connectivity of striatal seed regions.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291718003136_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>No diagnosis-specific differences were detected. The cross-disorder analysis, on the other hand, showed that increased functional connectivity between the left nucleus accumbens (NAcc) and a cluster in the right premotor cortex\/middle frontal gyrus was related to more severe symptoms of repetitive behaviour.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291718003136_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>We demonstrate the fruitfulness of applying a cross-disorder approach to investigate the neural underpinnings of compulsivity\/repetitive behaviour, by revealing a shared alteration in functional connectivity in ASD and OCD. We argue that this alteration might reflect aberrant reward or motivational processing of the NAcc with excessive connectivity to the premotor cortex implementing learned action patterns.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291718003136","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T09:31:01Z","timestamp":1540546261000},"page":"2247-2255","source":"Crossref","is-referenced-by-count":29,"title":["Frontostriatal functional connectivity correlates with repetitive behaviour across autism spectrum disorder and obsessive\u2013compulsive disorder"],"prefix":"10.1017","volume":"49","author":[{"given":"Sophie E.A.","family":"Akkermans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Rheinheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel 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