{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T02:27:44Z","timestamp":1792981664481,"version":"4.5.0"},"reference-count":87,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291718003203_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Early-life adversity (ELA) is a risk factor for internalizing psychopathology (IP). ELA is also linked to alterations in neural phenotypes of emotion processing and maladaptive emotion regulatory strategies, such as ruminative brooding, in adulthood. We therefore expected that ELA would predict cortical brain activation to emotional faces in transdiagnostic IP and in turn, mediate the extent of rumination amongst patients with IPs and ELA (IP + ELA).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291718003203_sec_a2\" sec-type=\"methods\"><jats:title>Method<\/jats:title><jats:p>One hundred and thirty-two individuals, including 102 treatment-seeking adults with heterogeneous IPs and 30 healthy controls (HCs) performed an Emotional Face-Matching Task during functional magnetic resonance imaging. Whole-brain analyses compared HC (<jats:italic>n<\/jats:italic> = 30), IP (<jats:italic>n<\/jats:italic> = 52), and IP + ELA (<jats:italic>n<\/jats:italic> = 50) neural responses to emotional (angry, fearful, happy, and sad) faces <jats:italic>v.<\/jats:italic> shapes, controlling for depression and anxiety symptoms. Parameter estimates of activation were extracted for significant between-group differences and tested as a mediator of ruminative brooding in IP + ELA.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291718003203_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>IP + ELA demonstrated increased activation in the superior frontal gyrus and anterior cingulate cortex (fear), superior parietal lobule, precuneus, posterior cingulate, and inferior temporal gyrus (fear only), and cuneus (fear and angry). These regions were preferentially correlated with ruminative brooding in IP + ELA, many of which mediated the link between IP + ELA and ruminative brooding.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291718003203_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Results provide evidence that ELA history amongst IP patients augments engagement of brain regions involved in emotion processing, above and beyond what is accounted for by current symptoms. Though longitudinal designs are needed, alterations in the neural correlates of maladaptive processing of socio-emotional information may be a common pathway by which ELA poses risk for psychopathology.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291718003203","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T10:06:17Z","timestamp":1542103577000},"page":"2267-2278","source":"Crossref","is-referenced-by-count":38,"title":["The roles of early-life adversity and rumination in neural response to emotional faces amongst anxious and depressed adults"],"prefix":"10.1017","volume":"49","author":[{"given":"Amy T.","family":"Peters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"Burkhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry 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