{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:28:24Z","timestamp":1791203304713,"version":"4.2.0"},"reference-count":121,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291718003306_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Aberrations in reward and penalty processing are implicated in depression and putatively reflect altered dopamine signalling. This study exploits the advantages of a placebo-controlled design to examine how a novel D\n                      <jats:sub>2<\/jats:sub>\n                      antagonist with adjunctive antidepressant properties modifies activity in the brain's reward network in depression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291718003306_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 43 medication-na\u00efve subjects across the range of depression severity (Beck's Depression Inventory-II score range: 0\u201343), including healthy volunteers, as well as people meeting full-criteria for major depressive disorder. In a double-blind placebo-controlled cross-over design, all subjects received either placebo or lurasidone (20 mg) across two visits separated by 1 week. Functional magnetic resonance imaging with the Monetary Incentive Delay (MID) task assessed reward functions via neural responses during anticipation and receipt of gains and losses. Arterial spin labelling measured cerebral blood flow (CBF) at rest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291718003306_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lurasidone altered fronto-striatal activity during anticipation and outcome phases of the MID task. A significant three-way Medication-by-Depression severity-by-Outcome interaction emerged in the anterior cingulate cortex (ACC) after correction for multiple comparisons. Follow-up analyses revealed significantly higher ACC activation to losses in high-\n                      <jats:italic>v.<\/jats:italic>\n                      low depression participants in the placebo condition, with a normalisation by lurasidone. This effect could not be accounted for by shifts in resting CBF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291718003306_sec_a4\" sec-type=\"conclusion\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lurasidone acutely normalises reward processing signals in individuals with depressive symptoms. Lurasidone's antidepressant effects may arise from reducing responses to penalty outcomes in individuals with depressive symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291718003306","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:22:29Z","timestamp":1546561349000},"page":"1365-1377","source":"Crossref","is-referenced-by-count":18,"title":["Modulation of anterior cingulate cortex reward and penalty signalling in medication-naive young-adult subjects with depressive symptoms following acute dose lurasidone"],"prefix":"10.1017","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6762-0456","authenticated-orcid":false,"given":"Selina A.","family":"Wolke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitul A.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"O'Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Zelaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Zahreddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Keren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"O'Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-6952","authenticated-orcid":false,"given":"Allan H.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Leibenluft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Pine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyris","family":"Stringaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"S0033291718003306_ref102","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF02253582","article-title":"D1 dopamine receptor-binding in mood disorders measured by positron emission tomography","volume":"106","author":"Suhara","year":"1992","journal-title":"Psychopharmacology"},{"key":"S0033291718003306_ref16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nn.3364","article-title":"Dopamine restores reward prediction errors in old age","volume":"16","author":"Chowdhury","year":"2013","journal-title":"Nature Neuroscience"},{"key":"S0033291718003306_ref79","first-page":"1","volume-title":"The Revised National Adult Reading Test\u2013Test Manual","author":"Nelson","year":"1991"},{"key":"S0033291718003306_ref111","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.10.014"},{"key":"S0033291718003306_ref32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s40262-016-0465-5","article-title":"Pharmacokinetics and pharmacodynamics of lurasidone hydrochloride, a second-generation antipsychotic: a systematic review of the published literature","volume":"56","author":"Greenberg","year":"2017","journal-title":"Clinical Pharmacokinetics"},{"key":"S0033291718003306_ref12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/npp.2010.151","article-title":"Opponency revisited: competition and cooperation between dopamine and serotonin","volume":"36","author":"Boureau","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"S0033291718003306_ref1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00213-006-0690-y","article-title":"Human reward system activation is modulated by a single dose of olanzapine in healthy subjects in an event-related, double-blind, placebo-controlled fMRI study","volume":"191","author":"Abler","year":"2007","journal-title":"Psychopharmacology"},{"key":"S0033291718003306_ref109","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jad.2014.04.003","article-title":"Efficacy of olanzapine monotherapy in the treatment of bipolar depression with mixed features","volume":"164","author":"Tohen","year":"2014","journal-title":"Journal of Affective Disorders"},{"key":"S0033291718003306_ref6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0010-440X(00)80007-3","article-title":"Depressive spectrum diagnoses","volume":"41","author":"Angst","year":"2000","journal-title":"Comprehensive Psychiatry"},{"key":"S0033291718003306_ref38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S2215-0366(17)30015-9","article-title":"How do antidepressants work? 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