{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:02:22Z","timestamp":1793134942271,"version":"4.5.0"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T00:00:00Z","timestamp":1548460800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291718004117_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mood and anxiety disorders are ubiquitous but current treatment options are ineffective for many sufferers. Moreover, a number of promising pre-clinical interventions have failed to translate into clinical efficacy in humans. Improved treatments are unlikely without better animal\u2013human translational pipelines. Here, we translate a rodent measure of negative affective bias into humans, exploring its relationship with (1) pathological mood and anxiety symptoms and (2) transient induced anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291718004117_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adult participants (age = 29 \u00b1 11) who met criteria for mood or anxiety disorder symptomatology according to a face-to-face neuropsychiatric interview were included in the symptomatic group. Study 1 included\n                      <jats:italic>N<\/jats:italic>\n                      = 77 (47 = asymptomatic [female = 21]; 30 = symptomatic [female = 25]), study 2 included\n                      <jats:italic>N<\/jats:italic>\n                      = 47 asymptomatic participants (25 = female). Outcome measures were choice ratios, reaction times and parameters recovered from a computational model of reaction time \u2013 the drift diffusion model (DDM) \u2013 from a two-alternative-forced-choice task in which ambiguous and unambiguous auditory stimuli were paired with high and low rewards.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291718004117_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups showed over 93% accuracy on unambiguous tones indicating intact discrimination, but symptomatic individuals demonstrated increased negative affective bias on ambiguous tones [proportion high reward = 0.42 (\n                      <jats:sc>s.d.<\/jats:sc>\n                      = 0.14)] relative to asymptomatic individuals [0.53 (\n                      <jats:sc>s.d.<\/jats:sc>\n                      = 0.17)] as well as a significantly reduced DDM drift rate. No significant effects were observed for the within-subjects anxiety-induction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291718004117_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Humans with pathological anxiety symptoms directly mimic rodents undergoing anxiogenic manipulation. The lack of sensitivity to transient anxiety suggests the paradigm might be more sensitive to clinically relevant symptoms. Our results establish a direct translational pipeline (and candidate therapeutics screen) from negative affective bias in rodents to pathological mood and anxiety symptoms in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291718004117","type":"journal-article","created":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T01:54:38Z","timestamp":1548467678000},"page":"237-246","source":"Crossref","is-referenced-by-count":43,"title":["Translating a rodent measure of negative bias into humans: the impact of induced anxiety and unmedicated mood and anxiety disorders"],"prefix":"10.1017","volume":"50","author":[{"given":"Jessica","family":"Aylward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-1132","authenticated-orcid":false,"given":"Oliver J.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,1,26]]},"reference":[{"key":"S0033291718004117_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.001"},{"key":"S0033291718004117_ref41","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.183"},{"key":"S0033291718004117_ref26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032511-143052"},{"key":"S0033291718004117_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2006.05.003"},{"key":"S0033291718004117_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/srep40094"},{"key":"S0033291718004117_ref29","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v035.i04"},{"key":"S0033291718004117_ref40","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01315"},{"key":"S0033291718004117_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1993.tb02055.x"},{"key":"S0033291718004117_ref46","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.59"},{"key":"S0033291718004117_ref27","doi-asserted-by":"publisher","DOI":"10.1080\/20445911.2011.584527"},{"key":"S0033291718004117_ref49","doi-asserted-by":"publisher","DOI":"10.1037\/a0019474"},{"key":"S0033291718004117_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(97)80006-X"},{"key":"S0033291718004117_ref50","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2013.00014"},{"key":"S0033291718004117_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(14)70305-0"},{"key":"S0033291718004117_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2932-5"},{"key":"S0033291718004117_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/srep24746"},{"key":"S0033291718004117_ref48","doi-asserted-by":"publisher","DOI":"10.3758\/BF03194023"},{"key":"S0033291718004117_ref42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147215"},{"key":"S0033291718004117_ref22","first-page":"25","article-title":"Augmentation strategies: focus on anxiolytics","volume":"57","author":"Joffe","year":"1996","journal-title":"The Journal of Clinical Psychiatry"},{"key":"S0033291718004117_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/4551057a"},{"key":"S0033291718004117_ref1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-011-0076-4"},{"key":"S0033291718004117_ref21","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198503682.001.0001","volume-title":"The Theory of probability","author":"Jeffreys","year":"1998"},{"key":"S0033291718004117_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.03.072"},{"key":"S0033291718004117_ref44","volume-title":"Manual for the State-Trait Anxiety Inventory","author":"Spielberger","year":"1983"},{"key":"S0033291718004117_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(97)83296-8"},{"key":"S0033291718004117_ref20","unstructured":"JASP (2016) JASP (Version 0.7.5.5). 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