{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:04:56Z","timestamp":1792854296190,"version":"4.5.0"},"reference-count":81,"publisher":"Cambridge University Press (CUP)","issue":"07","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291719000199_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Increased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations in error-monitoring are proposed as a transdiagnostic endophenotype. To strengthen this notion, data from unaffected individuals with a family history for the respective disorders are needed.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719000199_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>The error-related negativity (ERN) as a neural indicator of error-monitoring was measured during a flanker task from 117 OCD patients, 50 unaffected first-degree relatives of OCD patients, and 130 healthy comparison participants. Family history information indicated, that 76 healthy controls were free of a family history for psychopathology, whereas the remaining had first-degree relatives with depression (<jats:italic>n<\/jats:italic> = 28), anxiety (<jats:italic>n<\/jats:italic> = 27), and\/or SUD (<jats:italic>n<\/jats:italic> = 27).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719000199_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Increased ERN amplitudes were found in OCD patients and unaffected first-degree relatives of OCD patients. In addition, unaffected first-degree relatives of individuals with anxiety disorders were also characterized by increased ERN amplitudes, whereas relatives of individuals with SUD showed reduced amplitudes.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719000199_sec_a4\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Alterations in neural error-signals in unaffected first-degree relatives with a family history of OCD, anxiety, or SUD support the utility of the ERN as a transdiagnostic endophenotype. Reduced neural error-signals may indicate vulnerability for under-controlled behavior and risk for substance use, whereas a harm- or error-avoidant response style and vulnerability for OCD and anxiety appears to be associated with increased ERN. This adds to findings suggesting a common neurobiological substrate across psychiatric disorders involving the anterior cingulate cortex and deficits in cognitive control.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291719000199","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T03:47:30Z","timestamp":1549943250000},"page":"1207-1217","source":"Crossref","is-referenced-by-count":113,"title":["Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder"],"prefix":"10.1017","volume":"49","author":[{"given":"Anja","family":"Riesel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Klawohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Gr\u00fctzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Heinzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Bey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonhard","family":"Lennertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Kathmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"S0033291719000199_ref59","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14070886"},{"key":"S0033291719000199_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2013.04.007"},{"key":"S0033291719000199_ref57","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.10030416"},{"key":"S0033291719000199_ref56","year":"2019","journal-title":"Psychophysiology"},{"key":"S0033291719000199_ref55","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3746"},{"key":"S0033291719000199_ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2009.00848.x"},{"key":"S0033291719000199_ref53","volume":"7","year":"2013","journal-title":"Frontiers in Human Neuroscience"},{"key":"S0033291719000199_ref52","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"S0033291719000199_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.11.003"},{"key":"S0033291719000199_ref50","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-050212-185540"},{"key":"S0033291719000199_ref49","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12922"},{"key":"S0033291719000199_ref48","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000044"},{"key":"S0033291719000199_ref47","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.16040400"},{"key":"S0033291719000199_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2018.08.004"},{"key":"S0033291719000199_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.12.016"},{"key":"S0033291719000199_ref44","first-page":"350","volume":"7","year":"2013","journal-title":"Frontiers in Human Neuroscience"},{"key":"S0033291719000199_ref43","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt040"},{"key":"S0033291719000199_ref42","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130052"},{"key":"S0033291719000199_ref41","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12158"},{"key":"S0033291719000199_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.12.019"},{"key":"S0033291719000199_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.07.010"},{"key":"S0033291719000199_ref38","doi-asserted-by":"publisher","DOI":"10.1017\/S1352465812000665"},{"key":"S0033291719000199_ref37","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-014-0248-0"},{"key":"S0033291719000199_ref36","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579416000626"},{"key":"S0033291719000199_ref35","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.8"},{"key":"S0033291719000199_ref34","doi-asserted-by":"publisher","DOI":"10.1126\/science.1673802"},{"key":"S0033291719000199_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00243-4"},{"key":"S0033291719000199_ref32","doi-asserted-by":"publisher","DOI":"10.1159\/000360738"},{"key":"S0033291719000199_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.030"},{"key":"S0033291719000199_ref30","first-page":"1181","volume":"23","year":"2017","journal-title":"Molecular Psychiatry"},{"key":"S0033291719000199_ref29","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09091379"},{"key":"S0033291719000199_ref28","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab2358"},{"key":"S0033291719000199_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2016.07.516"},{"key":"S0033291719000199_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2011.02439.x"},{"key":"S0033291719000199_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2005.01.002"},{"key":"S0033291719000199_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20937"},{"key":"S0033291719000199_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-016-9826-5"},{"key":"S0033291719000199_ref22","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07010143"},{"key":"S0033291719000199_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.12.010"},{"key":"S0033291719000199_ref20","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.4.636"},{"key":"S0033291719000199_ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2010.04.003"},{"key":"S0033291719000199_ref80","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.2014.986430"},{"key":"S0033291719000199_ref19","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110048007"},{"key":"S0033291719000199_ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2206"},{"key":"S0033291719000199_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291716002786"},{"key":"S0033291719000199_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/1469-8986.3660667"},{"key":"S0033291719000199_ref15","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.14.4.485"},{"key":"S0033291719000199_ref79","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.7.675"},{"key":"S0033291719000199_ref14","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders, SCID, Clinician Version: User's Guide","year":"1996"},{"key":"S0033291719000199_ref78","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2015.11.012"},{"key":"S0033291719000199_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12002"},{"key":"S0033291719000199_ref77","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000019"},{"key":"S0033291719000199_ref12","doi-asserted-by":"publisher","DOI":"10.1037\/abn0000012"},{"key":"S0033291719000199_ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2015.02.029"},{"key":"S0033291719000199_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.03.024"},{"key":"S0033291719000199_ref75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2011.01206.x"},{"key":"S0033291719000199_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2008.04.002"},{"key":"S0033291719000199_ref74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209173271204"},{"key":"S0033291719000199_ref73","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0511(99)00032-0"},{"key":"S0033291719000199_ref72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.08.048"},{"key":"S0033291719000199_ref71","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.05.023"},{"key":"S0033291719000199_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(02)00182-2"},{"key":"S0033291719000199_ref69","first-page":"913","volume":"47","year":"2010","journal-title":"Psychophysiology"},{"key":"S0033291719000199_ref68","volume-title":"Manual for the State-Trait Anxiety Inventory","year":"1983"},{"key":"S0033291719000199_ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2012.01.012"},{"key":"S0033291719000199_ref66","first-page":"154","volume":"12","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"key":"S0033291719000199_ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2008.09.005"},{"key":"S0033291719000199_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2014.03.005"},{"key":"S0033291719000199_ref63","volume-title":"WST. Wortschatztest","year":"1992"},{"key":"S0033291719000199_ref62","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"S0033291719000199_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.04.022"},{"key":"S0033291719000199_ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2016.12.029"},{"key":"S0033291719000199_ref9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3286-05.2005"},{"key":"S0033291719000199_ref8","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.4.608"},{"key":"S0033291719000199_ref7","first-page":"3","volume":"109","year":"2014","journal-title":"Journal of Physiology-Paris"},{"key":"S0033291719000199_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/da.22035"},{"key":"S0033291719000199_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw157"},{"key":"S0033291719000199_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbm064"},{"key":"S0033291719000199_ref3","volume-title":"Manual for the Beck Depression Inventory-II","year":"1996"},{"key":"S0033291719000199_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.2008.00664.x"},{"key":"S0033291719000199_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2015.08.001"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291719000199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T04:36:47Z","timestamp":1556858207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291719000199\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":81,"journal-issue":{"issue":"07","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0033291719000199"],"URL":"https:\/\/doi.org\/10.1017\/s0033291719000199","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,12]]}}}