{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:00:09Z","timestamp":1792285209336,"version":"4.4.0"},"reference-count":78,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291719000369_sec_a1\" sec-type=\"other\"><jats:title>Background<\/jats:title><jats:p>Clozapine treatment increases the risk of agranulocytosis, but findings on the epidemiology of agranulocytosis have been inconsistent. This meta-analysis examined the prevalence of agranulocytosis and related death in clozapine-treated patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719000369_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A literature search in the international (PubMed, PsycINFO, and EMBASE) and Chinese (WanFang, Chinese National Knowledge Infrastructure, and Sinomed) databases was conducted. Prevalence estimates of agranulocytosis and related death in clozapine-treated patients were synthesized with the Comprehensive Meta-Analysis program using the random-effects model.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719000369_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Thirty-six studies with 260 948 clozapine-treated patients published between 1984 and 2018 were included in the meta-analysis. The overall prevalence of agranulocytosis and death caused by agranulocytosis were 0.4% (95% CI 0.3\u20130.6%) and 0.05% (95% CI 0.03\u20130.09%), respectively. The prevalence of agranulocytosis was moderated by sample size, study quality, year of publication, and that of data collection.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719000369_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of clozapine-associated agranulocytosis is low. Agranulocytosis-related death appears rare.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291719000369","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T06:21:40Z","timestamp":1552371700000},"page":"583-594","source":"Crossref","is-referenced-by-count":106,"title":["The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies"],"prefix":"10.1017","volume":"50","author":[{"given":"Xiao-Hong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Mei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-wang","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee H.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor S.","family":"Ungvari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-0029","authenticated-orcid":false,"given":"Yu-Tao","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"S0033291719000369_ref78","first-page":"116","article-title":"Comparison of the effects of clozapine and chlorpromazine on white blood cells (in Chinese)","volume":"4","author":"Zhu","year":"1992","journal-title":"Shanghai Archives of 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