{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:09:43Z","timestamp":1787497783005,"version":"build-2736575974"},"reference-count":72,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291719001144_sec_a1\" sec-type=\"other\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Schizophrenia is associated with robust hippocampal volume deficits but subregion volume deficits, their associations with cognition, and contributing genes remain to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291719001144_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Hippocampal formation (HF) subregion volumes were obtained using FreeSurfer 6.0 from individuals with schizophrenia (\n                      <jats:italic>n<\/jats:italic>\n                      = 176, mean age \u00b1\n                      <jats:sc>s.d.<\/jats:sc>\n                      = 39.0 \u00b1 11.5, 132 males) and healthy volunteers (\n                      <jats:italic>n<\/jats:italic>\n                      = 173, mean age \u00b1\n                      <jats:sc>s.d.<\/jats:sc>\n                      = 37.6 \u00b1 11.3, 123 males) with similar mean age, gender, handedness, and race distributions. Relationships between the HF subregion volume with the largest between group difference, neuropsychological performance, and single-nucleotide polymorphisms were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291719001144_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study found a significant group by region interaction on hippocampal subregion volumes. Compared to healthy volunteers, individuals with schizophrenia had significantly smaller dentate gyrus (DG) (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      = \u22120.57), Cornu Ammonis (CA) 4, molecular layer of the hippocampus, hippocampal tail, and CA 1 volumes, when statistically controlling for intracranial volume; DG (\n                      <jats:italic>d<\/jats:italic>\n                      = \u22120.43) and CA 4 volumes remained significantly smaller when statistically controlling for mean hippocampal volume. DG volume showed the largest between group difference and significant positive associations with visual memory and speed of processing in the overall sample. Genome-wide association analysis with DG volume as the quantitative phenotype identified rs56055643 (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 10.8,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 5 \u00d7 10\n                      <jats:sup>\u22128<\/jats:sup>\n                      , 95% CI 7.0\u201314.5) on chromosome 3 in high linkage disequilibrium with\n                      <jats:italic>MOBP<\/jats:italic>\n                      . Gene-based analyses identified associations between\n                      <jats:italic>SLC25A38<\/jats:italic>\n                      and\n                      <jats:italic>RPSA<\/jats:italic>\n                      and DG volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291719001144_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study suggests that DG dysfunction is fundamentally involved in schizophrenia pathophysiology, that it may contribute to cognitive abnormalities in schizophrenia, and that underlying biological mechanisms may involve contributions from\n                      <jats:italic>MOBP<\/jats:italic>\n                      ,\n                      <jats:italic>SLC25A38<\/jats:italic>\n                      , and\n                      <jats:italic>RPSA<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291719001144","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T04:13:53Z","timestamp":1559535233000},"page":"1267-1277","source":"Crossref","is-referenced-by-count":30,"title":["Dentate gyrus volume deficit in schizophrenia"],"prefix":"10.1017","volume":"50","author":[{"given":"Soichiro","family":"Nakahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vince D.","family":"Calhoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin O.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryon","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan R.","family":"Bustillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"O'Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McEwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Voyvodic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysenil","family":"Belger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Mathalon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Macciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyuki","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Potkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-2797","authenticated-orcid":false,"given":"Theo G. M.","family":"van Erp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,6,3]]},"reference":[{"key":"S0033291719001144_ref41","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.209"},{"key":"S0033291719001144_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2013.04.005"},{"key":"S0033291719001144_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.10.028"},{"key":"S0033291719001144_ref8a","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0024-16.2016"},{"key":"S0033291719001144_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"S0033291719001144_ref71","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3668-12.2012"},{"key":"S0033291719001144_ref64","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5"},{"key":"S0033291719001144_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/ng.859"},{"key":"S0033291719001144_ref46","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000137"},{"key":"S0033291719001144_ref11","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1111\/acer.12140","article-title":"Neurocognition in 1-month-abstinent treatment-seeking alcohol-dependent individuals: interactive effects of age and chronic cigarette smoking","volume":"37","author":"Durazzo","year":"2013","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"S0033291719001144_ref65","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09960"},{"key":"S0033291719001144_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23572"},{"key":"S0033291719001144_ref62","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20615"},{"key":"S0033291719001144_ref61","first-page":"235","article-title":"Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRI","volume":"11","author":"Van Leemput","year":"2008","journal-title":"Medical Image Computing and Computer-Assisted Intervention: MICCAI \u2026 International Conference on Medical Image Computing and Computer-Assisted Intervention"},{"key":"S0033291719001144_ref60","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.24.8.1123.8375"},{"key":"S0033291719001144_ref54","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.149"},{"key":"S0033291719001144_ref58","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09081187"},{"key":"S0033291719001144_ref53","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3085"},{"key":"S0033291719001144_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.12.004"},{"key":"S0033291719001144_ref57","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.118"},{"key":"S0033291719001144_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.10.003"},{"key":"S0033291719001144_ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.08.042"},{"key":"S0033291719001144_ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0430-y"},{"key":"S0033291719001144_ref68","first-page":"510","article-title":"Shape-based alignment of hippocampal subfields: evaluation in postmortem MRI","volume":"11","author":"Yushkevich","year":"2008","journal-title":"Medical Image Computing and Computer-Assisted Intervention: MICCAI \u2026 International Conference on Medical Image Computing and Computer-Assisted Intervention"},{"key":"S0033291719001144_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.09.012"},{"key":"S0033291719001144_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2017.06.006"},{"key":"S0033291719001144_ref47","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5281.1516"},{"key":"S0033291719001144_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.5"},{"key":"S0033291719001144_ref14","volume-title":"User's Guide for the Structured Clinical Interview for DSM-IV-TR Axis I Disorders: SCID-I","author":"First","year":"2002"},{"key":"S0033291719001144_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-007-9003-9"},{"key":"S0033291719001144_ref59","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs062"},{"key":"S0033291719001144_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.019"},{"key":"S0033291719001144_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx108"},{"key":"S0033291719001144_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.08.067"},{"key":"S0033291719001144_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20583"},{"key":"S0033291719001144_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.10.002"},{"key":"S0033291719001144_ref10","volume-title":"Four Factor Index of Social Status","author":"de Belmont Hollingshead","year":"1975"},{"key":"S0033291719001144_ref6","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16020201"},{"key":"S0033291719001144_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-7039-x"},{"key":"S0033291719001144_ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002812"},{"key":"S0033291719001144_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"S0033291719001144_ref52","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbn150"},{"key":"S0033291719001144_ref32","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2016.1199893"},{"key":"S0033291719001144_ref35","doi-asserted-by":"publisher","DOI":"10.1192\/S0007125000291514"},{"key":"S0033291719001144_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.06.020"},{"key":"S0033291719001144_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"S0033291719001144_ref63","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.56"},{"key":"S0033291719001144_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.07.012"},{"key":"S0033291719001144_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.08.012"},{"key":"S0033291719001144_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/srep45494"},{"key":"S0033291719001144_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2016.11.002"},{"key":"S0033291719001144_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs118"},{"key":"S0033291719001144_ref40","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-6-12"},{"key":"S0033291719001144_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.028"},{"key":"S0033291719001144_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"S0033291719001144_ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003098"},{"key":"S0033291719001144_ref23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/318596"},{"key":"S0033291719001144_ref45","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"S0033291719001144_ref34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117785"},{"key":"S0033291719001144_ref3","first-page":"3","volume-title":"Progress in Brain Research","volume":"216","author":"Amaral","year":"2007"},{"key":"S0033291719001144_ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.12.039"},{"key":"S0033291719001144_ref36","doi-asserted-by":"publisher","DOI":"10.1097\/00001504-200503000-00004"},{"key":"S0033291719001144_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90424-7"},{"key":"S0033291719001144_ref30","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.4"},{"key":"S0033291719001144_ref37","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.453"},{"key":"S0033291719001144_ref67","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00261"},{"key":"S0033291719001144_ref21","doi-asserted-by":"publisher","DOI":"10.21767\/2171-6625.1000159"},{"key":"S0033291719001144_ref39","doi-asserted-by":"publisher","DOI":"10.1002\/npr2.12031"},{"key":"S0033291719001144_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2014.02.011"},{"key":"S0033291719001144_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184661"},{"key":"S0033291719001144_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22691"},{"key":"S0033291719001144_ref51","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.115"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291719001144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T21:15:49Z","timestamp":1721337349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291719001144\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,3]]},"references-count":72,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0033291719001144"],"URL":"https:\/\/doi.org\/10.1017\/s0033291719001144","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,3]]}}}