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One hundred seventy-two remitted patients newly diagnosed with BD, 52 of their unaffected relatives (UR), and 110 healthy controls (HC) were compared on a large battery of behavioural cognitive tasks tapping into non-affective (i.e. neurocognitive) and affective (i.e. emotion processing and regulation) cognition.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719001867_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Relative to HCs, patients with BD exhibited global neurocognitive deficits (<jats:italic>p<\/jats:italic>s &lt; 0.001), as well as aberrant emotion processing and regulation (<jats:italic>p<\/jats:italic>s \u2a7d 0.011); including decreased emotional reactivity to positive social scenarios, impaired ability to down-regulate positive emotion, as well as a specific deficit in the ability to recognise surprised facial expressions. Their URs also showed a trend towards difficulties identifying surprised faces (<jats:italic>p<\/jats:italic> = 0.075). No other differences in cognitive function were found for URs compared to HCs.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719001867_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Neurocognitive deficits and impairments within emotion processing and regulation may be illness-related deficits of BD that present after illness-onset, whereas processing of emotional faces may represent an early risk marker of BD. However, longitudinal studies are needed to examine the association between cognitive impairments and illness progression in BD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291719001867","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T10:41:10Z","timestamp":1566988870000},"page":"1808-1819","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":33,"title":["Aberrant cognition in newly diagnosed patients with bipolar disorder and their unaffected relatives"],"prefix":"10.1017","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-8853","authenticated-orcid":false,"given":"Hanne 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