{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:22:32Z","timestamp":1790526152086,"version":"4.1.0"},"reference-count":59,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291719002988_sec_a1\"><jats:title>Background<\/jats:title><jats:p>The pathophysiology of obsessive-compulsive disorder (OCD) remains unclear despite extensive neuroimaging work on the disorder. Exposure to medication and comorbid mental disorders can confound the results of OCD studies. The goal of this study was to explore differences in brain functional connectivity (FC) within the cortico-striato-thalamo-cortical (CSTC) loop of drug-na\u00efve and drug-free OCD patients and healthy controls (HCs).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719002988_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>A total of 29 drug-na\u00efve OCD patients, 22 drug-free OCD patients, and 25 HCs matched on age, gender and education level underwent functional magnetic resonance imaging scanning at resting state. Seed-based connectivity analyses were conducted among the three groups. The Yale Brown Obsessive Compulsive Scale and clinical inventories were used to assess the clinical symptoms.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719002988_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Compared with HCs, the drug-na\u00efve OCD patients had reduced FC within the limbic CSTC loop. In the drug-na\u00efve OCD participants, we also found hyperconnectivity between the supplementary motor area and ventral and dorsal putamen (<jats:italic>p<\/jats:italic> &lt; 0.05, corrected for multiple comparisons).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291719002988_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Exposure to antidepressants such as selective serotonin reuptake inhibitors may affect the function of some brain regions. Future longitudinal studies could help to reveal the pharmacotherapeutic mechanisms in these loops.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291719002988","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T17:11:08Z","timestamp":1571850668000},"page":"70-82","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":32,"title":["Limbic cortico-striato-thalamo-cortical functional connectivity in drug-na\u00efve patients of obsessive-compulsive disorder"],"prefix":"10.1017","volume":"51","author":[{"given":"Qing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-5314","authenticated-orcid":false,"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"S0033291719002988_ref47","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.euroneuro.2009.11.007","article-title":"Region- 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