{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:14:52Z","timestamp":1776276892382,"version":"3.50.1"},"reference-count":60,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291720000471_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Postpartum psychosis (PP) is a severe postpartum disorder. While working memory and emotional processing-related brain function are consistently impaired in psychoses unrelated to the puerperium, no studies have investigated them in PP.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291720000471_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Twenty-four women at risk of developing PP (11 developed an episode \u2013 PE; 13 remained well \u2013 NPE) and 20 healthy postpartum women completed two functional magnetic resonance imaging tasks within a year of delivery: working memory (<jats:italic>n<\/jats:italic>-back) and emotional face recognition (fearful faces). We compared women at-risk of PP to controls, as well as NPE, PE, and controls to test for potential effects of a PP episode occurrence.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291720000471_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Women at-risk of PP and PE showed hyperactivation of lateral visual areas, precuneus, and posterior cingulate during the<jats:italic>n<\/jats:italic>-back task. The at-risk group as a whole, as well as the PE and NPE groups, showed hyperconnectivity of the right dorsolateral prefrontal cortex (DLPFC) with various parieto-occipito-temporo-cerebellar regions compared to controls during several<jats:italic>n<\/jats:italic>-back conditions. Increases in connectivity between the right DLPFC and ipsilateral middle temporal gyrus were observed in the PE group compared to NPE during 2-back. During the fearful faces task, at-risk women as a group showed hyperactivation of fronto-cingulo-subcortical regions, and hypoconnectivity between the left amygdala and ipsilateral occipito-parietal regions compared to controls. No significant performance differences were observed.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291720000471_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>These results present preliminary evidence of a differential nature of functional brain abnormalities in PP compared to the typically observed reduced connectivity with the DLPFC in psychoses unrelated to puerperium, such as bipolar disorder.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291720000471","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T10:06:19Z","timestamp":1584353179000},"page":"1724-1732","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["Neurocognitive correlates of working memory and emotional processing in postpartum psychosis: an fMRI study"],"prefix":"10.1017","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6543-290X","authenticated-orcid":false,"given":"Olivia S.","family":"Kowalczyk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid M.","family":"Pauls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Fust\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Hazelgrove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza","family":"Vecchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gertrude","family":"Seneviratne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine M.","family":"Pariante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Dazzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitul A.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"S0033291720000471_ref44","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.9.1603"},{"key":"S0033291720000471_ref30","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.12.2103"},{"key":"S0033291720000471_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.12.009"},{"key":"S0033291720000471_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2007.00404.x"},{"key":"S0033291720000471_ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000352011"},{"key":"S0033291720000471_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2011.00893.x"},{"key":"S0033291720000471_ref38","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.91"},{"key":"S0033291720000471_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0003-8"},{"key":"S0033291720000471_ref42","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.21.2582"},{"key":"S0033291720000471_ref23","volume-title":"IBM SPSS Statistics for Macintosh","year":"2016"},{"key":"S0033291720000471_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20138"},{"key":"S0033291720000471_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2011.02.011"},{"key":"S0033291720000471_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.09.033"},{"key":"S0033291720000471_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2010.12.005"},{"key":"S0033291720000471_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.12.007"},{"key":"S0033291720000471_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06850.x"},{"key":"S0033291720000471_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.02.008"},{"key":"S0033291720000471_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.05.026"},{"key":"S0033291720000471_ref51","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2006.15.352"},{"key":"S0033291720000471_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.12.014"},{"key":"S0033291720000471_ref54","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ajmg.b.30964","article-title":"An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder","volume":"153","author":"Thermenos","year":"2010","journal-title":"American Journal of Medical Genetics. 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