{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:57:26Z","timestamp":1794329846166,"version":"4.9.0"},"reference-count":58,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291720002457_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Although deficits in affective processing are a core component of anorexia nervosa (AN), we lack a detailed characterization of the neurobiological underpinnings of emotion regulation impairment in AN. Moreover, it remains unclear whether these neural correlates scale with clinical outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291720002457_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We investigated the neural correlates of negative emotion regulation in a sample of young women receiving day-hospital treatment for AN (<jats:italic>n<\/jats:italic>= 21) and healthy controls (<jats:italic>n<\/jats:italic>= 21). We aimed to determine whether aberrant brain activation patterns during emotion regulation predicted weight gain following treatment in AN patients and were linked to AN severity. To achieve this, participants completed a cognitive reappraisal paradigm during functional magnetic resonance imaging. Skin conductance response, as well as subjective distress ratings, were recorded to corroborate task engagement.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291720002457_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Compared to controls, patients with AN showed reduced activation in the dorsolateral prefrontal cortex (dlPFC) during cognitive reappraisal [pFWE&lt;0.05, threshold-free cluster enhancement (TFCE) corrected]. Importantly, psycho\u2013physiological interaction analysis revealed reduced functional connectivity between the dlPFC and the amygdala in AN patients during emotion regulation (pFWE&lt;0.05, TFCE corrected), and dlPFC-amygdala uncoupling was associated with emotion regulation deficits (<jats:italic>r<\/jats:italic>= \u22120.511,<jats:italic>p<\/jats:italic>= 0.018) and eating disorder severity (<jats:italic>r<\/jats:italic>= \u22120.565,<jats:italic>p<\/jats:italic>= .008) in the AN group. Finally, dlPFC activity positively correlated with increases in body mass index (<jats:italic>r<\/jats:italic>= 0.471,<jats:italic>p<\/jats:italic>= 0.042) and in body fat mass percentage (<jats:italic>r<\/jats:italic>= 0.605,<jats:italic>p<\/jats:italic>= 0.008) following 12 weeks of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291720002457_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Taken together, our findings indicate that individuals with AN present altered fronto-amygdalar response during cognitive reappraisal and that this response may serve as a predictor of response to treatment and be linked to clinical severity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291720002457","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T08:10:29Z","timestamp":1595491829000},"page":"844-852","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":36,"title":["Dorsolateral 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