{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:01:21Z","timestamp":1790179281687,"version":"4.1.0"},"reference-count":60,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291720002482_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Given the prevalence of adolescent depression and the modest effects of current treatments, research ought to inform development of effective intervention strategies. Self-compassion is inversely associated with depression, and self-compassion interventions have demonstrated promising effects on reducing depression. However, little is known about the neural mechanisms underlying that relationship. Maladaptive self-processing is a characteristic of depression that contributes to the onset and chronicity of depression. Because our own face is an automatic and direct cue for self-processing, this study investigated whether self-compassion was associated with neural responses during sad\n                      <jats:italic>v<\/jats:italic>\n                      . neutral self-face recognition and explore their relationship with depression severity in depressed adolescents and healthy controls (HCs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291720002482_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>During functional magnetic resonance imaging, 81 depressed youth and 37 HCs were instructed to identify whether morphed self or other faces with sad, happy, or neutral expressions resembled their own.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291720002482_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Self-compassion correlated negatively with activity during sad\n                      <jats:italic>v<\/jats:italic>\n                      . neutral self-face recognition in the dorsal anterior cingulate cortex in the total sample, and in the right posterior cingulate cortex\/precuneus in HCs, respectively. In depressed adolescents, higher self-compassion correlated with lower activity during sad\n                      <jats:italic>v<\/jats:italic>\n                      . neutral self-face recognition in the right dorsolateral prefrontal cortex (DLPFC), implying that less cognitive effort might be needed to avoid dwelling on sad self-faces and\/or regulate negative affect induced by them. Moreover, higher self-compassion mediated the relationship between lower DLPFC activity and reduced depression severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291720002482_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings imply that DLPFC activity might be a biological marker of a successful self-compassion intervention as potential treatment for adolescent depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291720002482","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T03:54:00Z","timestamp":1595476440000},"page":"864-873","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":33,"title":["Self-compassion and dorsolateral prefrontal cortex activity during sad self-face recognition in depressed 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