{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:45:30Z","timestamp":1786999530956,"version":"build-2736575974"},"reference-count":72,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0033291720002949_sec_a1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Patients with post-traumatic stress disorder (PTSD) show a different stress-related cognitive style compared with healthy controls (HC). The\n                      <jats:italic>FK506 binding protein 5<\/jats:italic>\n                      gene (\n                      <jats:italic>FKBP5<\/jats:italic>\n                      ), one of the PTSD known risk factors, is involved in the stress response through the hypothalamic-pituitary-adrenal axis and brain volumetric alterations. The present study aimed to uncover the neural correlates of stress-related cognitive styles through the analysis of the regional brain volumes and\n                      <jats:italic>FKBP5<\/jats:italic>\n                      genotype in patients with PTSD compared with HC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291720002949_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, 51 patients with PTSD and 94 HC were assessed for stress-related cognitive styles, PTSD symptoms severity, and genotype of\n                      <jats:italic>FKBP5<\/jats:italic>\n                      single nucleotide polymorphisms, and underwent T1-weighted structural magnetic resonance imaging. Diagnosis-by-genotype interaction for regional brain volumes was examined in 16 brain regions of interest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291720002949_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with PTSD showed significantly higher levels of catastrophizing, ruminative response, and repression, and reduced distress aversion and positive reappraisal compared with HC (\n                      <jats:italic>p &lt;<\/jats:italic>\n                      0.001). Significant diagnosis-by-genotype interactions for regional brain volumes were observed for bilateral hippocampi and left frontal operculum. A significant positive correlation between the severity of the repression and left hippocampal volume was found in a subgroup of patients with PTSD with\n                      <jats:italic>FKBP5<\/jats:italic>\n                      rs3800373 (AA genotype) or rs1360780 (CC genotype).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291720002949_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The present study showed the influences of\n                      <jats:italic>FKBP5<\/jats:italic>\n                      genotype on the distorted cognitive styles in PTSD by measuring the volumetric alteration of hippocampal regions, providing a possible role of the hippocampus and left frontal operculum as significant neurobiological correlates of PTSD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0033291720002949","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T02:18:22Z","timestamp":1599445102000},"page":"1243-1254","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Stress-related cognitive style is related to volumetric change of the hippocampus and FK506 binding protein 5 polymorphism in post-traumatic stress disorder"],"prefix":"10.1017","volume":"52","author":[{"given":"Je-Yeon","family":"Yun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungkean","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-3709","authenticated-orcid":false,"given":"Seung-Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"S0033291720002949_ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.02.015"},{"key":"S0033291720002949_ref46","first-page":"2728","article-title":"Distinct genetic influences on cortical surface area and cortical thickness","volume":"19","author":"Panizzon","year":"2009","journal-title":"Cerebral Cortex (New York. 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