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Precise and powerful estimates of digital intervention effectiveness for anxiety disorders are necessary for further adoption in practice. The present systematic review and meta-analysis examined the effectiveness of digital interventions across all anxiety disorders and specific to each disorder\n                      <jats:italic>v.<\/jats:italic>\n                      wait-list and care-as-usual controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291721001999_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of bibliographic databases identified 15 030 abstracts from inception to 1 January 2020. Forty-seven randomized controlled trials (53 comparisons; 4958 participants) contributed to the meta-analysis. Subgroup analyses were conducted by an anxiety disorder, risk of bias, treatment support, recruitment, location and treatment adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291721001999_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A large, pooled effect size of\n                      <jats:italic>g<\/jats:italic>\n                      = 0.80 [95% Confidence Interval: 0.68\u20130.93] was found in favor of digital interventions. Moderate to large pooled effect sizes favoring digital interventions were found for generalized anxiety disorder (\n                      <jats:italic>g<\/jats:italic>\n                      = 0.62), mixed anxiety samples (\n                      <jats:italic>g<\/jats:italic>\n                      = 0.68), panic disorder with or without agoraphobia (\n                      <jats:italic>g<\/jats:italic>\n                      = 1.08) and social anxiety disorder (\n                      <jats:italic>g<\/jats:italic>\n                      = 0.76) subgroups. No subgroups were significantly different or related to the pooled effect size. Notably, the effects of guided interventions (\n                      <jats:italic>g<\/jats:italic>\n                      = 0.84) and unguided interventions (\n                      <jats:italic>g<\/jats:italic>\n                      = 0.64) were not significantly different. Supplemental analysis comparing digital and face-to-face interventions (9 comparisons; 683 participants) found no significant difference in effect [\n                      <jats:italic>g<\/jats:italic>\n                      = 0.14 favoring digital interventions; Confidence Interval: \u22120.01 to 0.30].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0033291721001999_sec_a4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The precise and powerful estimates found further justify the application of digital interventions for anxiety disorders in place of wait-list or usual care.<\/jats:p>\n                  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