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This requires participants to sequentially play four simple games, with transition between games being made either voluntarily (executive condition) or automatically (control condition).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721002452_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>CMET performance was impaired in the manic patients compared to the healthy controls. Manic patients failed to increase activation in the lateral frontal, cingulate and inferior parietal cortex when the executive demands of the task increased, while this increase was observed in the healthy controls. Activity in these regions was associated with task performance.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721002452_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Manic patients show evidence of impaired goal management, which is associated with a pattern of reduced medial and lateral frontal and parietal activity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291721002452","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T08:44:16Z","timestamp":1628153056000},"page":"1021-1029","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Brain correlates of impaired goal management in bipolar 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