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Prevalence estimates and 95% CI were calculated using a random-effect model. Subgroup analyses and meta-regressions to identify sources and the amount of heterogeneity were also conducted.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721002853_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The search yielded 4143 articles. After the removal of duplicates, 2473 abstracts and titles were screened. At the full-text stage, 112 were screened, 18 articles were included in a systematic review and 13 articles in the main statistical analysis. The prevalence of MetS in na\u00efve (0 days) FEP is 13.2% (95% CI 8.7\u201319.0). Ethnicity accounted for 3% of the heterogeneity between studies, and diagnostic criteria used for MetS accounted for 7%. When compared with controls matched by sex and age, the odds ratio is 2.52 (95% CI 1.29\u20135.07; <jats:italic>p<\/jats:italic> = 0.007).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721002853_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our findings of increased rates of MetS in na\u00efve FEP patients suggest that we are underestimating cardiovascular risk in this population, especially in those of non-Caucasian origin. Our findings support that altered metabolic parameters in FEPs are not exclusively due to antipsychotic treatments.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291721002853","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T02:41:51Z","timestamp":1631068911000},"page":"2307-2320","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":64,"title":["Metabolic syndrome in antipsychotic-na\u00efve patients with first-episode psychosis: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1810-947X","authenticated-orcid":false,"given":"Nathalia","family":"Garrido-Torres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idalino","family":"Rocha-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alameda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Rodriguez-Gangoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vilches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Canal-Rivero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-7132","authenticated-orcid":false,"given":"Benedicto","family":"Crespo-Facorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Ruiz-Veguilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"S0033291721002853_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.6.681"},{"key":"S0033291721002853_ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2147-x"},{"key":"S0033291721002853_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2009.03.025"},{"key":"S0033291721002853_ref10","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.114596"},{"key":"S0033291721002853_ref45","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000054"},{"key":"S0033291721002853_ref65","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.0304"},{"key":"S0033291721002853_ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.3.356"},{"key":"S0033291721002853_ref40","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108093927"},{"key":"S0033291721002853_ref64","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12251"},{"key":"S0033291721002853_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-019-0075-y"},{"key":"S0033291721002853_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"S0033291721002853_ref6","doi-asserted-by":"publisher","DOI":"10.5551\/jat.13.202"},{"key":"S0033291721002853_ref36","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.411"},{"key":"S0033291721002853_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"S0033291721002853_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00310-7"},{"key":"S0033291721002853_ref9","unstructured":"Borenstein, M. , Hedges, L. , Higgins, J. , & Rothstein, H. 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