{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:39:50Z","timestamp":1790278790128,"version":"4.1.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291721003329_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Anxiety disorders are the most prevalent mental disorder in children and young people. Developing effective therapy for these children is critical to reduce mental disorders across the lifespan. The study aimed to evaluate the efficacy of combining cognitive behavioural therapy (CBT) and sertraline (SERT) in the treatment of anxiety in youth, using a double-blind randomised control trial design.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721003329_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Ninety-nine youth (ages 7\u201315 years) with an anxiety disorder were randomly allocated to either individual (CBT) and SERT or individual CBT and pill placebo and assessed again immediately and 6 months after treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721003329_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>There were no significant differences between conditions in remission of primary anxiety disorder or all anxiety disorders. Furthermore, there were no significant differences in rates of change in diagnostic severity, parent-reported anxiety symptoms, child-reported anxiety symptoms or life interference due to anxiety.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721003329_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The efficacy of CBT for children and adolescents with anxiety disorders is not significantly enhanced by combination with a short-term course of anti-depressants over and above the combined effects of pill placebo.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291721003329","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T09:35:35Z","timestamp":1630402535000},"page":"1741-1749","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Combining CBT and sertraline does not enhance outcomes for anxious youth: a double-blind randomised controlled trial"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5778-2670","authenticated-orcid":false,"given":"Jennifer L.","family":"Hudson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren F.","family":"McLellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valsamma","family":"Eapen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Rapee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Wuthrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi J.","family":"Lyneham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,8,31]]},"reference":[{"key":"S0033291721003329_ref13","volume-title":"The cool kids anxiety treatment program","author":"Rapee","year":"2006"},{"key":"S0033291721003329_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10567-005-4753-0"},{"key":"S0033291721003329_ref9","unstructured":"Limited, T. 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