{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:46:28Z","timestamp":1784299588005,"version":"3.55.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH111263"],"award-info":[{"award-number":["R01MH111263"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1RR024979"],"award-info":[{"award-number":["UL1RR024979"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291721003640_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Prior work supports delayed gastric emptying in anorexia nervosa and bulimia nervosa (BN) but not binge-eating disorder, suggesting that neither low body weight nor binge eating fully accounts for slowed gastric motility. Specifying a link between delayed gastric emptying and self-induced vomiting could offer new insights into the pathophysiology of purging disorder (PD).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721003640_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Women (<jats:italic>N<\/jats:italic> = 95) recruited from the community meeting criteria for DSM-5 BN who purged (<jats:italic>n<\/jats:italic> = 26), BN with nonpurging compensatory behaviors (<jats:italic>n<\/jats:italic> = 18), PD (<jats:italic>n<\/jats:italic> = 25), or healthy control women (<jats:italic>n<\/jats:italic> = 26) completed assessments of gastric emptying, gut peptides, and subjective responses over the course of a standardized test meal under two conditions administered in a double-blind, crossover sequence: placebo and 10 mg of metoclopramide.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721003640_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Delayed gastric emptying was associated with purging with no main or moderating effects of binge eating in the placebo condition. Medication eliminated group differences in gastric emptying but did not alter group differences in reported gastrointestinal distress. Exploratory analyses revealed that medication caused increased postprandial PYY release, which predicted elevated gastrointestinal distress.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721003640_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Delayed gastric emptying demonstrates a specific association with purging behaviors. However, correcting disruptions in gastric emptying may exacerbate disruptions in gut peptide responses specifically linked to the presence of purging after normal amounts of food.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291721003640","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T06:59:56Z","timestamp":1630997996000},"page":"1947-1954","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Disentangling the links between gastric emptying and binge eating <i>v<\/i>. purging in eating disorders using a case-control design"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6542-5147","authenticated-orcid":false,"given":"Pamela K.","family":"Keel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Eckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britny A.","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa A.","family":"Haedt-Matt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J.","family":"Murry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Appelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Jimerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"S0033291721003640_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291719003982"},{"key":"S0033291721003640_ref19","first-page":"41","article-title":"Gastric emptying in patients with bulimia nervosa and anorexia nervosa","volume":"85","author":"Hutson","year":"1990","journal-title":"The American Journal of Gastroenterology"},{"key":"S0033291721003640_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22806"},{"key":"S0033291721003640_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90083-W"},{"key":"S0033291721003640_ref37","volume-title":"The state-trait anxiety inventory","author":"Spielberger","year":"1983"},{"key":"S0033291721003640_ref40","first-page":"291","article-title":"The mean cumulative fraction absorbed-time profiles of paracetamol as an index of gastric emptying","volume":"12","author":"van Wyk","year":"1990","journal-title":"Methods and Findings in Experimental and Clinical Pharmacology"},{"key":"S0033291721003640_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22788"},{"key":"S0033291721003640_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92954-1"},{"key":"S0033291721003640_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004"},{"key":"S0033291721003640_ref15","doi-asserted-by":"publisher","DOI":"10.2174\/1568007033338715"},{"key":"S0033291721003640_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.11.063"},{"key":"S0033291721003640_ref4","doi-asserted-by":"publisher","DOI":"10.1592\/phco.23.1.5.31919"},{"key":"S0033291721003640_ref31","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1993.10718337"},{"key":"S0033291721003640_ref42","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011935603893"},{"key":"S0033291721003640_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(85)90010-8"},{"key":"S0033291721003640_ref27","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.3.259"},{"key":"S0033291721003640_ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1998.00080.x"},{"key":"S0033291721003640_ref29","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.155.159"},{"key":"S0033291721003640_ref1","unstructured":"Baliga, V. , & Kallury, K. 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