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Analyses utilized Aalen's linear hazards models.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721005134_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Risk for AUD was robustly predicted by the main effects of FGRS<jats:sub>AUD<\/jats:sub> [<jats:italic>b<\/jats:italic> = 6.32 (95% CI 6.21\u20136.43), <jats:italic>z<\/jats:italic> = 64.9, <jats:italic>p<\/jats:italic> &lt; 0.001) and GAEA [<jats:italic>b<\/jats:italic> = \u22122.90 (2.83\u20132.97), <jats:italic>z<\/jats:italic> = 44.1, <jats:italic>p<\/jats:italic> &lt; 0.001] and their interaction [<jats:italic>b<\/jats:italic> = \u22121.93 (1.83\u20132.03), <jats:italic>z<\/jats:italic> = 32.9, <jats:italic>p<\/jats:italic> &lt; 0.001]. Results were similar for the prediction of DUD by the main effects of FGRS<jats:sub>DUD<\/jats:sub> [<jats:italic>b<\/jats:italic> = 4.65 (CI 4.56\u20134.74), <jats:italic>z<\/jats:italic> = 59.4, <jats:italic>p<\/jats:italic> &lt; 0.001] and GAEA [\u22122.08 (2.03\u20132.13), <jats:italic>z<\/jats:italic> = 46.4, <jats:italic>p<\/jats:italic> &lt; 0.001] and their interaction [<jats:italic>b<\/jats:italic> = \u22121.58 (1.50\u20131.66)), <jats:italic>z<\/jats:italic> = 30.2, <jats:italic>p<\/jats:italic> &lt; 0.001]. The magnitude of the interactions between GAEA and FGRS<jats:sub>AUD<\/jats:sub> and FGRS<jats:sub>DUD<\/jats:sub> in the prediction of, respectively, AUD and DUD was attenuated only slightly by the addition of educational attainment to the model.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721005134_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusions and relevance<\/jats:title><jats:p>The genetic propensity to high educational attainment robustly moderates the genetic risk for both AUD and DUD such that the impact of the genetic liability to AUD and DUD on the risk of illness is substantially attenuated in those with high <jats:italic>v.<\/jats:italic> low GAEA. This effect is not appreciably mediated by the actual level of educational attainment. These naturalistic findings could form the basis of prevention efforts in high-risk youth.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291721005134","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T07:45:12Z","timestamp":1640245512000},"page":"3077-3084","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["The moderation of the genetic risk for alcohol and drug use disorders in a Swedish national sample by the genetic aptitude for educational attainment"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-6570","authenticated-orcid":false,"given":"Kenneth 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