{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:06:14Z","timestamp":1791576374928,"version":"4.3.4"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0033291721005171_sec_a1\"><jats:title>Background<\/jats:title><jats:p>Social anxiety disorder (SAD) is common, first-line treatments are often only partially effective, and reliable predictors of treatment response are lacking. Here, we assessed resting state functional connectivity (rsFC) at pre-treatment and during early treatment as a potential predictor of response to a novel attention bias modification procedure, gaze-contingent music reward therapy (GC-MRT).<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721005171_sec_a2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>Thirty-two adults with SAD were treated with GC-MRT. rsFC was assessed with multi-voxel pattern analysis of fMRI at pre-treatment and after 2\u20133 weeks. For comparison, 20 healthy control (HC) participants without treatment were assessed twice for rsFC over the same time period. All SAD participants underwent clinical evaluation at pre-treatment, early-treatment (week 2\u20133), and post-treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721005171_sec_a3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>SAD and depressive symptoms improved significantly from pre-treatment to post-treatment. After 2\u20133 weeks of treatment, decreased connectivity between the executive control network (ECN) and salience network (SN), and increased connectivity within the ECN predicted improvement in SAD and depressive symptoms at week 8. Increased connectivity between the ECN and default mode network (DMN) predicted greater improvement in SAD but not depressive symptoms at week 8. Connectivity within the DMN decreased significantly after 2\u20133 weeks of treatment in the SAD group, while no changes were found in HC over the same time interval.<\/jats:p><\/jats:sec><jats:sec id=\"S0033291721005171_sec_a4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>We identified early changes in rsFC during a course of GC-MRT for SAD that predicted symptom change. Connectivity changes within the ECN, ECN-DMN, and ECN-SN may be related to mechanisms underlying the clinical effects of GC-MRT and warrant further study in controlled trials.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0033291721005171","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T06:07:13Z","timestamp":1647929233000},"page":"3115-3123","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Resting state connectivity predictors of symptom change during gaze-contingent music reward therapy of social anxiety disorder"],"prefix":"10.1017","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-2901","authenticated-orcid":false,"given":"Xi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Lazarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Bar-Haim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A","family":"Pizzagalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Schneier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"S0033291721005171_ref13","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"S0033291721005171_ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015238"},{"key":"S0033291721005171_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.010"},{"key":"S0033291721005171_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2018.03.002"},{"key":"S0033291721005171_ref37","first-page":"322","article-title":"Functional impairment in social phobia","volume":"55","author":"Schneier","year":"1994","journal-title":"Journal of Clinical Psychiatry"},{"key":"S0033291721005171_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.039"},{"key":"S0033291721005171_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.05.005"},{"key":"S0033291721005171_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.02.013"},{"key":"S0033291721005171_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171500238X"},{"key":"S0033291721005171_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.012"},{"key":"S0033291721005171_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9375-7"},{"key":"S0033291721005171_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"S0033291721005171_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.04.037"},{"key":"S0033291721005171_ref44","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22234"},{"key":"S0033291721005171_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.02.045"},{"key":"S0033291721005171_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/da.22014"},{"key":"S0033291721005171_ref38","doi-asserted-by":"publisher","DOI":"10.1002\/da.23089"},{"key":"S0033291721005171_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"S0033291721005171_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu316"},{"key":"S0033291721005171_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.07.014"},{"key":"S0033291721005171_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.12.038"},{"key":"S0033291721005171_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.05.028"},{"key":"S0033291721005171_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.05.029"},{"key":"S0033291721005171_ref26","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01227-8"},{"key":"S0033291721005171_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.104"},{"key":"S0033291721005171_ref46","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"S0033291721005171_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.003"},{"key":"S0033291721005171_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2015.06.001"},{"key":"S0033291721005171_ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01154-6"},{"key":"S0033291721005171_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.11.020"},{"key":"S0033291721005171_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.11.076"},{"key":"S0033291721005171_ref2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00830.2009"},{"key":"S0033291721005171_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.12.011"},{"key":"S0033291721005171_ref20","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16080894"},{"key":"S0033291721005171_ref28","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-4-7"},{"key":"S0033291721005171_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.01.001"},{"key":"S0033291721005171_ref27","doi-asserted-by":"publisher","DOI":"10.1177\/10738584211030497"},{"key":"S0033291721005171_ref36","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.534983"},{"key":"S0033291721005171_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0071"},{"key":"S0033291721005171_ref39","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr099"},{"key":"S0033291721005171_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.11.005"},{"key":"S0033291721005171_ref48","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0904-8"},{"key":"S0033291721005171_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9705-0_5"},{"key":"S0033291721005171_ref9","first-page":"473","article-title":"Functional connectivity between anterior insula and key nodes of frontoparietal executive control and salience networks distinguish bipolar depression from unipolar depression and healthy control subjects","volume":"3","author":"Ellard","year":"2018","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"S0033291721005171_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s13587-014-0014-5"},{"key":"S0033291721005171_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171700366X"},{"key":"S0033291721005171_ref45","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.109"},{"key":"S0033291721005171_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq237"},{"key":"S0033291721005171_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.022"},{"key":"S0033291721005171_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102615"}],"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291721005171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T11:07:25Z","timestamp":1711451245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291721005171\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0033291721005171"],"URL":"https:\/\/doi.org\/10.1017\/s0033291721005171","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,22]]},"assertion":[{"value":"Copyright \u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}